Bartoloni C, Dupont P, Feltkamp H, Johnston C I, Steinbach K, Zilcher H, Kaindl F
Istituto di Clinica Medica Generale e Terapia Medica, Universita Cattolica S. Cuore, Rome, Italy.
Eur J Clin Pharmacol. 1988;35(6):573-7. doi: 10.1007/BF00637591.
The antihypertensive effect of ketanserin 40 mg b.d. in combination with a beta-adrenergic blocking agent or a diuretic was assessed in an open study in 35 patients with essential hypertension, who had not responded to treatment with beta-blockers, diuretics or their combination. The ketanserin/beta-blocker combination decreased mean sitting systolic/diastolic blood pressure (SBP/DBP) from 169/107 mmHg to 156/91 mmHg at the end of the 12-week active treatment period. The decrease in systolic blood pressure was significant only at Week 8, while the decrease in diastolic blood pressure was highly significant at all times. A significant reduction in heart rate by 10 beats.min-1 was observed with the ketanserin + beta-blocker combination. The ketanserin/diuretic combination led to a significant reduction in mean SBP/DBP from 164/106 mmHg to 146/92 mmHg after 12 weeks, with no significant change in heart rate. Body weight slightly increased in both groups. There were significantly fewer adverse reactions with the ketanserin/diuretic combination than with the ketanserin/beta-blocker combination. The results indicate a potentially useful therapeutic role for ketanserin in combination with beta-blockers or diuretics.
在一项开放性研究中，对35例原发性高血压患者评估了40毫克酮色林每日两次联合β-肾上腺素能阻滞剂或利尿剂的降压效果，这些患者对β受体阻滞剂、利尿剂或其联合治疗均无反应。在为期12周的积极治疗期结束时，酮色林/β受体阻滞剂联合用药使平均坐位收缩压/舒张压（SBP/DBP）从169/107毫米汞柱降至156/91毫米汞柱。收缩压仅在第8周时显著下降，而舒张压在所有时间均显著下降。酮色林 + β受体阻滞剂联合用药使心率显著降低10次·分钟-1。酮色林/利尿剂联合用药在12周后使平均SBP/DBP从164/106毫米汞柱显著降至146/92毫米汞柱，心率无显著变化。两组患者体重均略有增加。酮色林/利尿剂联合用药的不良反应明显少于酮色林/β受体阻滞剂联合用药。结果表明，酮色林与β受体阻滞剂或利尿剂联合使用可能具有有益的治疗作用。
