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Novel Mutations on EGFR Leu792 Potentially Correlate to Acquired Resistance to Osimertinib in Advanced NSCLC.

作者信息

Chen Kai, Zhou Fei, Shen Wenxiang, Jiang Tao, Wu Xue, Tong Xiaoling, Shao Yang W, Qin Songbing, Zhou Caicun

机构信息

Department of Medical Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.

Department of Oncology, Shanghai Pulmonary Hospital, Cancer Institute of Tongji University Medical School, Shanghai, People's Republic of China.

出版信息

J Thorac Oncol. 2017 Jun;12(6):e65-e68. doi: 10.1016/j.jtho.2016.12.024. Epub 2017 Jan 16.

DOI:10.1016/j.jtho.2016.12.024
PMID:28093244
Abstract
摘要

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Novel Mutations on EGFR Leu792 Potentially Correlate to Acquired Resistance to Osimertinib in Advanced NSCLC.表皮生长因子受体（EGFR）Leu792位点的新型突变可能与晚期非小细胞肺癌对奥希替尼的获得性耐药相关。
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Sequential liquid biopsies reveal dynamic alterations of EGFR driver mutations and indicate EGFR amplification as a new mechanism of resistance to osimertinib in NSCLC.连续液体活检揭示了EGFR驱动基因突变的动态变化，并表明EGFR扩增是NSCLC中对奥希替尼耐药的一种新机制。
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Osimertinib (AZD9291) and CNS Response in Two Radiotherapy-Naïve Patients with EGFR-Mutant and T790M-Positive Advanced Non-Small Cell Lung Cancer.奥希替尼（AZD9291）与两名未经放疗的EGFR突变且T790M阳性的晚期非小细胞肺癌患者的中枢神经系统反应
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Emerging EML4-ALK Variant 5 as a Concurrent Resistance Mechanism to Osimertinib in a Patient With EGFR E19del/T790M NSCLC.新型EML4-ALK变异体5作为EGFR E19del/T790M非小细胞肺癌患者对奥希替尼的同时性耐药机制
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Uncommon EGFR G724S mutations arise in non-small-cell lung cancer patients with acquired resistance to first-generation EGFR-TKIs.罕见的表皮生长因子受体（EGFR）G724S突变出现在对第一代EGFR酪氨酸激酶抑制剂产生获得性耐药的非小细胞肺癌患者中。
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