Mejia-Munne Juan C, Ellis Jason A, Feldstein Neil A, Meyers Philip M, Connolly Edward S
Department of Neurosurgery, University of Cincinnati Medical Center, Cincinnati, Ohio, USA.
Department of Neurosurgery, Columbia University Medical Center, New York, USA.
World Neurosurg. 2017 Apr;100:575-578. doi: 10.1016/j.wneu.2017.01.012. Epub 2017 Jan 16.
More than 50 years have elapsed since moyamoya disease was initially described; however, the disease etiology remains unknown. Although certain genetic loci and immunologic characteristics are associated with moyamoya disease, this does not fully explain its pathophysiology. An association with inflammatory disease has been postulated but not rigorously explored. We sought to examine the epidemiologic association of moyamoya and inflammatory diseases by analyzing data from a large administrative database.
The National Inpatient Sample database for 2009-2012 was obtained. The diagnoses of moyamoya disease and inflammatory diseases were made using the International Classification of Disease, 9th revision. Sample prevalence, sex, age, and admission type were recorded. Patients were grouped into inflammatory disease clusters on the basis of the presence of diagnosis codes for atherosclerotic, adult-onset autoimmune, and juvenile-onset autoimmune diseases.
There were 2633 total admissions for moyamoya disease. Atherosclerotic (P < 0.05) and juvenile-onset autoimmune disease (P < 0.05) were associated with moyamoya disease in both pediatric and adult patient groups. Adult-onset autoimmune disease was associated with moyamoya disease in pediatric (P < 0.05) but not adult groups.
Moyamoya is associated with inflammatory disease clusters in both pediatric and adult populations. Further studies are warranted to investigate the pathophysiologic association between moyamoya disease and inflammatory disease processes.
自烟雾病最初被描述以来已经过去了50多年；然而，该疾病的病因仍然不明。尽管某些基因位点和免疫特征与烟雾病有关，但这并不能完全解释其病理生理学。有人推测它与炎症性疾病有关，但尚未进行严格的研究。我们试图通过分析一个大型行政数据库的数据来研究烟雾病与炎症性疾病之间的流行病学关联。
获取了2009 - 2012年的全国住院患者样本数据库。使用国际疾病分类第九版对烟雾病和炎症性疾病进行诊断。记录样本患病率、性别、年龄和入院类型。根据动脉粥样硬化、成人发病的自身免疫性疾病和青少年发病的自身免疫性疾病的诊断代码，将患者分为炎症性疾病组。
烟雾病患者共有2633例入院记录。在儿童和成人患者组中，动脉粥样硬化（P < 0.05）和青少年发病的自身免疫性疾病（P < 0.05）均与烟雾病有关。成人发病的自身免疫性疾病在儿童组中与烟雾病有关（P < 0.05），但在成人组中无关。
烟雾病在儿童和成人人群中均与炎症性疾病组有关。有必要进一步研究以探讨烟雾病与炎症性疾病过程之间的病理生理关联。
