Yi Jongyoun, Kim Kye-Hyung, Ko Mee Kyung, Lee Eun Yup, Choi Su Jin, Oh Myoung-Don
Department of Laboratory Medicine, Pusan National University School of Medicine, Busan, South Korea.
Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea.
Am J Trop Med Hyg. 2017 Apr;96(4):777-782. doi: 10.4269/ajtmh.16-0309. Epub 2017 Jan 16.
AbstractHuman granulocytic anaplasmosis (HGA) is a tick-borne rickettsial zoonosis with fever, thrombocytopenia, and leukopenia. HGA has been reported in Korea in 2013 but it is uncertain how long it has existed. A retrospective study was conducted on patients who underwent bone marrow examination due to fever and cytopenia, with no clear hematologic or microbiologic causes, from 2003 through 2012. Laboratory diagnosis was made by detecting 16S rRNA genes of from the stored blood samples. Among the 70 patients, five (7.1%) HGA cases were found, and the earliest case dated back to 2006. Two cases met the diagnostic criteria of hemophagocytic lymphohistiocytosis (HLH) and were fatal. Although HGA has been prevalent in Korea since at least 2006, it is not always diagnosed and has posed a possible lethal health risk to the people in Korea. HGA should be considered as a cause of fever with cytopenia or HLH.
人粒细胞无形体病（HGA）是一种由蜱传播的立克次体人畜共患病，症状包括发热、血小板减少和白细胞减少。2013年韩国曾报告过人粒细胞无形体病，但不确定其存在了多长时间。对2003年至2012年期间因发热和血细胞减少而接受骨髓检查、但无明确血液学或微生物学病因的患者进行了一项回顾性研究。通过检测储存血样中的无形体16S rRNA基因进行实验室诊断。在70例患者中，发现了5例（7.1%）人粒细胞无形体病病例，最早的病例可追溯到2006年。2例符合噬血细胞性淋巴组织细胞增生症（HLH）的诊断标准，均死亡。尽管人粒细胞无形体病至少自2006年以来在韩国就很普遍，但并非总能得到诊断，对韩国民众构成了可能致命的健康风险。人粒细胞无形体病应被视为血细胞减少或HLH引起发热的一个病因。
