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基于自组装4-(1,2-二苯基丁-1-烯-1-基)苯胺的纳米颗粒：以鬼臼毒素和芦荟大黄素为构建单元

Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks.

作者信息

Fumagalli Gaia, Christodoulou Michael S, Riva Benedetta, Revuelta Inigo, Marucci Cristina, Collico Veronica, Prosperi Davide, Riva Sergio, Perdicchia Dario, Bassanini Ivan, García-Argáez Aida, Via Lisa Dalla, Passarella Daniele

机构信息

Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy.

Dipartimento di Biotecnologie e Bioscienze - Università degli Studi di Milano Bicocca, Piazza della scienza 2, 20126 Milano, Italy.

出版信息

Org Biomol Chem. 2017 Feb 1;15(5):1106-1109. doi: 10.1039/c6ob02591a.

DOI:10.1039/c6ob02591a
PMID:28093593
Abstract

The ability of 4-(1,2-diphenylbut-1-en-1-yl)aniline as a self-assembly inducer is reported. The conjugation of this moiety with aloin or podophyllotoxin resulted in spherical nanoparticles that were characterized by Dynamic Light Scattering (DLS), Transmission Electron Microscopy (TEM) and NanoSight technology. A preliminary biological evaluation on two cancer cell lines is reported.

摘要

据报道，4-（1,2-二苯基丁-1-烯-1-基）苯胺作为一种自组装诱导剂的能力。该部分与芦荟素或鬼臼毒素的共轭作用产生了球形纳米颗粒，通过动态光散射（DLS）、透射电子显微镜（TEM）和纳米视技术对其进行了表征。报道了对两种癌细胞系的初步生物学评估。

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