Doane Ashley S, Elemento Olivier
HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Wiley Interdiscip Rev Syst Biol Med. 2017 May;9(3). doi: 10.1002/wsbm.1374. Epub 2017 Jan 17.
Regulatory elements determine the connectivity of molecular networks and mediate a variety of regulatory processes ranging from DNA looping to transcriptional, posttranscriptional, and posttranslational regulation. This review highlights our current understanding of the different types of regulatory elements found in molecular networks with a focus on DNA regulatory elements. We highlight technical advances and current challenges for the mapping of regulatory elements at the genome-wide scale, and describe new computational methods to uncover these elements via reconstructing regulatory networks from large genomic datasets. WIREs Syst Biol Med 2017, 9:e1374. doi: 10.1002/wsbm.1374 For further resources related to this article, please visit the WIREs website.
调控元件决定分子网络的连通性,并介导从DNA环化到转录、转录后和翻译后调控等多种调控过程。本综述着重介绍了我们目前对分子网络中不同类型调控元件的理解,重点是DNA调控元件。我们强调了在全基因组范围内绘制调控元件的技术进展和当前挑战,并描述了通过从大型基因组数据集中重建调控网络来发现这些元件的新计算方法。WIREs系统生物学与医学2,017, 9:e1374。doi: 10.1002/wsbm.1374 有关本文的更多资源,请访问WIREs网站。