Cawley J C, Burns G F, Worman C P, Flemans R J, Sibbald R, Barker C R, Roberts B E
Scand J Haematol. 1978 Sep;21(3):233-42. doi: 10.1111/j.1600-0609.1978.tb00358.x.
Morphological and immunological marker data on a patient with 'pure' monocytic leukaemia are presented and compared with those of 6 cases of clearly mixed myelomonocytic leukaemia with a variable monocytic component. In all patients studied, the leukaemic monocytes expressed a receptor for the Fc of IgG, and IgG sensitization markedly enhanced phagocytosis of ox erythrocytes. A variable, but lower, percentage of the leukaemic monocytes had a receptor for mouse C3, but the cells uniformly lacked surface immunoglobulin and receptors for the Fc of IgM and for unsensitised mouse erythrocytes. Cytochemical and ultrastructural study also showed no clear difference between the monocytes of the 'pure' and mixed monocytic leukaemias. This report therefore lends no support to the concept of distinct types of monocytic leukaemia.
本文呈现了一名“纯”单核细胞白血病患者的形态学和免疫标记数据，并与6例具有不同单核细胞成分的明显混合性髓单核细胞白血病病例的数据进行了比较。在所有研究的患者中，白血病单核细胞均表达IgG Fc受体，IgG致敏显著增强了对牛红细胞的吞噬作用。白血病单核细胞中有可变但较低比例的细胞具有小鼠C3受体，但这些细胞均缺乏表面免疫球蛋白以及IgM Fc受体和未致敏小鼠红细胞的受体。细胞化学和超微结构研究也显示，“纯”单核细胞白血病和混合性单核细胞白血病的单核细胞之间没有明显差异。因此，本报告不支持存在不同类型单核细胞白血病这一概念。
