人类急性单核细胞白血病细胞的表面膜特性

Surface membrane characteristics of cells from human acute monocytic leukaemia.

作者信息

Parker A C, Dewar A E, Wilson C D, Young S, Stuart A E

出版信息

Scand J Haematol. 1978 May;20(5):467-78. doi: 10.1111/j.1600-0609.1978.tb02484.x.

DOI:10.1111/j.1600-0609.1978.tb02484.x

Abstract

The clinical and laboratory features of 4 patients with acute monocytic leukaemia are described. Surface membrane receptor studies of these patients have shown increasing strength of receptor expression occurs with increasing morphological maturity of the monocyte. In addition, the study shows that expression of membrane receptors can vary from patient to patient and also with time and treatment in an individual patient. A further finding has been the loss of positivity with specific anti-monocyte serum when the disease becomes refractory to therapy.

摘要

本文描述了4例急性单核细胞白血病患者的临床和实验室特征。对这些患者的表面膜受体研究显示，随着单核细胞形态学成熟度的增加，受体表达强度也在增加。此外，研究表明，膜受体的表达在患者之间可能存在差异，并且在个体患者中也会随时间和治疗而变化。另一个发现是，当疾病对治疗产生耐药性时，特异性抗单核细胞血清的阳性反应会消失。