Xu Jingyao, Zhou Xiaoling, Li Yifei, Tian Yudan
The Affiliated Hospital to Changchun University of Chinese Medicine, 1478 Gongnong Road, Changchun. China.
Curr Drug Metab. 2017;18(4):266-279. doi: 10.2174/1389200218666170116113103.
Nanotechnology is a multidisciplinary field, which have the potential to cover applications in many subjects such as biology, chemistry and physics.
The combined efforts of these subjects can lead to the successful engineering of nanodevices and nanovectors for targeted delivery and sensing/detection of cancer cells/tissues. The modulation of nanomaterials at surface and bulk level further adds value to this technology and develop strategies for early detection of precancerous and malignant cells from biological fluids. Furthermore, the novel nanotechnology-based imaging modalities have the prospects to offer non-invasive cancer imaging and treatment response study in real-time.
This review covers the advantages of nanotechnology, which have been exploited for effective and targeted delivery of anti-cancer agents.
Moreover, the initiatives taken by National Cancer Laboratory, USA to improve the clinical success of nanomedicines and nanovectors have also been comprehensively summarized.
纳米技术是一个多学科领域，有潜力涵盖生物学、化学和物理学等许多学科的应用。
这些学科的共同努力能够成功设计出用于癌细胞/组织靶向递送和传感/检测的纳米器件和纳米载体。在表面和整体水平对纳米材料进行调控进一步提升了该技术的价值，并开发出从生物流体中早期检测癌前细胞和恶性细胞的策略。此外，新型基于纳米技术的成像方式有望提供非侵入性癌症成像及实时治疗反应研究。
本综述涵盖了纳米技术的优势，这些优势已被用于抗癌药物的有效靶向递送。
此外，还全面总结了美国国家癌症实验室为提高纳米药物和纳米载体的临床成功率所采取的举措。
