DNA 编码化合物库作为开源：新药研发的强大途径。
DNA-Encoded Compound Libraries as Open Source: A Powerful Pathway to New Drugs.
机构信息
The Scripps Research Institute, 10550 North Torrey Pines Road, MB-10, La Jolla, CA 92037, USA.
出版信息
Angew Chem Int Ed Engl. 2017 Jan 24;56(5):1164-1165. doi: 10.1002/anie.201612143.
"… We envisioned an iterative system where a unique DNA tag identifier that encoded the event was appended to each newly formed molecule. These vast collections of molecules are known today as DNA- encoded chemical libraries (DECLs), and allow scientists to do selections on the benchtop that previously required access to large and complex high-throughput screening centers …" Read more in the Guest Editorial by Richard A. Lerner and Sydney Brenner.
“……我们设想了一个迭代系统，其中每个新形成的分子都附加了一个唯一的 DNA 标签标识符，该标识符对事件进行了编码。这些庞大的分子集合现在被称为 DNA 编码化学文库 (DECL)，使科学家能够在台式机上进行以前需要访问大型和复杂的高通量筛选中心才能完成的选择……”在 Richard A. Lerner 和 Sydney Brenner 的客座社论中了解更多信息。
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