University Department of Dermatology and Allergology, Ulm, Germany.
Department of Dermatology and Allergology, Helios Klinik Rottweil, Rottweil, Germany.
Exp Dermatol. 2017 Sep;26(9):830-832. doi: 10.1111/exd.13286. Epub 2017 Apr 11.
UVA-1 is a known promotor of skin ageing. Cytokines like IL-1α, Il-1β or TNF-α, VEGF and IL-6 orchestrate UV effects, and IL-6 is furthermore an effector of UVA-induced photoageing. We investigated how fractionated UVA-1 doses influence the cytokine milieu and especially the IL-6 levels in the skin in vivo. In a study with 35 participants, we exposed previously unirradiated human skin to three UVA-1 irradiation regimes. Cytokine levels in interstitial skin fluid were measured up to 48 hours postexposure and compared to unirradiated control skin fluid. Our results show that IL-6 levels increased significantly after UVA-1 exposure at selected time points. The other candidates IL-1α, Il-1β or TNF-α and VEGF show no significant response after UVA-1 exposure in vivo. UVA-1 thus raises selectively IL-6 levels in vivo, a fact that underlines its role in photoageing and has potential implications for its modulatory effect on photoageing pathology.
UVA-1 是已知的皮肤老化促进剂。细胞因子，如 IL-1α、Il-1β 或 TNF-α、VEGF 和 IL-6 协调紫外线的作用，而 IL-6 又是 UVA 诱导光老化的效应物。我们研究了分段 UVA-1 剂量如何影响细胞因子环境，特别是体内皮肤中的 IL-6 水平。在一项有 35 名参与者参与的研究中，我们将以前未辐照的人体皮肤暴露于三种 UVA-1 辐照方案下。在辐照后长达 48 小时测量间质皮肤液中的细胞因子水平，并与未辐照的对照皮肤液进行比较。我们的结果表明，在选定的时间点，IL-6 水平在 UVA-1 暴露后显著增加。其他候选物 IL-1α、Il-1β 或 TNF-α 和 VEGF 在体内 UVA-1 暴露后没有明显的反应。因此，UVA-1 选择性地提高了体内的 IL-6 水平，这一事实强调了它在光老化中的作用，并可能对其对光老化病理的调节作用产生影响。
