Endocr Pract. 2017 Apr 2;23(4):391-398. doi: 10.4158/EP161623.OR. Epub 2017 Jan 17.
The aims of our study were to establish reference values for insulin-like growth factor 1 (IGF-1) in Lebanese schoolchildren and to evaluate the relationship between IGF-1 and age, sex, body mass index (BMI), vitamin D, and ferritin.
This cross-sectional study included 952 Lebanese schoolchildren (495 boys and 457 girls) aged 8 to 18 years. Blood samples were taken from children attending 10 schools with different socio-economic status (SES). Chemiluminescent immunoassays were used for IGF-1, 25 hydroxyvitamin D (25(OH)D), testosterone, and ferritin measurements.
The mean age was 13.46 ± 2.80 with no significant difference according to sex. IGF-1 was correlated with age in both sexes (P<.0001); it was higher in girls compared to boys (P = .007) and peaked at the ages of 14 and 12 for boys and girls, respectively. For each age group, the median IGF-1 value was higher compared to the values provided by the kit. IGF-1 was significantly correlated with BMI in boys (r = 0.16, P<.0001) but not girls. In both sexes, IGF-1 was inversely correlated with 25(OH)D and ferritin values. After adjustment for age, BMI, and height, the correlation between IGF-1 and 25(OH)D disappeared, whereas the relationship with ferritin persisted (P<.001 for boys, P = .002 for girls). For both sexes, multivariate regression analysis revealed independent associations between IGF-1 and height, Tanner stage, and ferritin. An association was also noted in boys for BMI and testosterone.
Our results showed higher and earlier peak IGF-1 values in the pediatric Lebanese population compared to western populations. In addition, an independent inverse relationship was observed between IGF-1 and ferritin. Further studies are needed to identify the reason(s) underlying these results.
BMI = body mass index CRP = C-reactive protein CV = coefficient of variation GH = growth hormone IGF-1 = insulin-like growth factor 1 25(OH)D = 25 hydroxyvitamin D SES = socio-economic status TSH = thyroid-stimulating hormone.
我们的研究旨在建立黎巴嫩学童胰岛素样生长因子 1（IGF-1）的参考值，并评估 IGF-1 与年龄、性别、体重指数（BMI）、维生素 D 和铁蛋白之间的关系。
本横断面研究纳入了 952 名年龄在 8 至 18 岁的黎巴嫩学童（男 495 名，女 457 名）。从 10 所具有不同社会经济地位（SES）的学校抽取儿童血样。使用化学发光免疫分析测定 IGF-1、25 羟维生素 D（25（OH）D）、睾酮和铁蛋白。
平均年龄为 13.46±2.80，男女之间无显著差异。IGF-1 在两性中均与年龄相关（P<0.0001）；与男孩相比，女孩的 IGF-1 更高（P=0.007），男孩和女孩的 IGF-1 峰值分别出现在 14 岁和 12 岁。对于每个年龄组，中位数 IGF-1 值均高于试剂盒提供的值。IGF-1 与男孩的 BMI 显著相关（r=0.16，P<0.0001），但与女孩无关。在两性中，IGF-1 与 25（OH）D 和铁蛋白值呈负相关。在调整年龄、BMI 和身高后，IGF-1 与 25（OH）D 之间的相关性消失，而与铁蛋白的相关性仍然存在（男孩 P<0.001，女孩 P=0.002）。对于两性，多元回归分析显示 IGF-1 与身高、Tanner 分期和铁蛋白独立相关。在男孩中，BMI 和睾酮也存在相关性。
与西方人群相比，我们的研究结果显示黎巴嫩儿科人群的 IGF-1 峰值更高且更早。此外，IGF-1 与铁蛋白之间存在独立的负相关关系。需要进一步的研究来确定这些结果的原因。
BMI=体重指数 CRP=C-反应蛋白 CV=变异系数 GH=生长激素 IGF-1=胰岛素样生长因子 1 25（OH）D=25 羟维生素 D SES=社会经济地位 TSH=促甲状腺激素。
