Department of Endocrinology, Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon.
Division of Endocrinology, Hotel-Dieu de France Hospital, Beirut, Lebanon.
Sci Rep. 2020 Nov 26;10(1):20620. doi: 10.1038/s41598-020-77689-5.
Lipoprotein a (Lp(a) is an independent risk factor for atherosclerotic cardiovascular disease. The prevalence of high Lipoprotein (a) (Lp(a)) in the Lebanese pediatric population is unknown. Our study aims to assess this prevalence and to study the relationship of Lp(a) with the lipid profile, age, body mass index (BMI) and socio-economic status (SES) in Lebanese schoolchildren. A total of 961 children aged 8-18 years (497 boys and 464 girls) were recruited from ten private and public schools in 2013-2014 using a stratified random sample. Schools were selected from the Greater Beirut and Mount Lebanon areas, and were categorized into three subgroups according to the schools' SES status (high, medium, low). Lp(a) was assayed in 2018 on samples previously frozen at - 80 °C. Abnormal Lp(a) levels (≥ 75 nmol/L) were observed in 14.4% of the overall sample (13.5% for boys,15.3% of girls p = 0.56). The median of Lp(a) was 20(10-50) in the whole sample with no significant gender difference. No significant relationship was found between Lp(a) and age. However, Lp(a) was significantly correlated with BMI in whole sample, as well as in boys and girls (p = 0.02, p = 0.03, p = 0.03, respectively). A significant correlation was found between Lp(a) and non-HDL-C in the whole sample as well as in boys and girls (respectively p < 0.001,p = 0.024 and p = 0.03), but not with triglycerides and HDL-C. In a multivariate linear regression analysis, Lp(a) was only independently associated with BMI and non-HDL-C in boys and girls. Lp(a) was independently associated with BMI and non-HDL-C while no significant relationship was observed with age and sex confirming the strong genetic determination of Lp(a).
脂蛋白(a)（Lp(a)）是动脉粥样硬化性心血管疾病的独立危险因素。高脂蛋白(a)（Lp(a)）在黎巴嫩儿科人群中的患病率尚不清楚。我们的研究旨在评估这种患病率，并研究 Lp(a)与黎巴嫩学童的血脂谱、年龄、体重指数（BMI）和社会经济地位（SES）之间的关系。2013 年至 2014 年，采用分层随机抽样的方法，从 10 所私立和公立学校中招募了 961 名 8-18 岁的儿童（497 名男孩和 464 名女孩）。学校选自大贝鲁特和黎巴嫩山地区，并根据学校 SES 状况（高、中、低）分为三组。2018 年，对之前在-80°C 下冷冻的样本进行了 Lp(a)测定。在整个样本中，有 14.4%的人存在异常的 Lp(a)水平（≥75nmol/L）（男孩为 13.5%，女孩为 15.3%，p=0.56）。整个样本中 Lp(a)的中位数为 20（10-50），性别之间无显著差异。Lp(a)与年龄之间未发现显著关系。然而，Lp(a)与整个样本以及男孩和女孩的 BMI 呈显著相关（p=0.02，p=0.03，p=0.03）。Lp(a)与整个样本以及男孩和女孩的非高密度脂蛋白胆固醇（分别为 p<0.001，p=0.024 和 p=0.03）呈显著相关，但与甘油三酯和高密度脂蛋白胆固醇无关。在多元线性回归分析中，Lp(a)仅与男孩和女孩的 BMI 和非高密度脂蛋白胆固醇独立相关。Lp(a)与 BMI 和非高密度脂蛋白胆固醇独立相关，而与年龄和性别无显著关系，这证实了 Lp(a)的强遗传决定作用。
