骨桥蛋白基因多态性与结直肠癌的关联

Association of Osteopontin Gene Polymorphisms with Colorectal Cancer.

作者信息

Kamal Asmaa, Darwish Rania Kamal, Saad Samar, Salama Mohamed, El-Baradie Tarek S, Mahmoud Heba G M, Elshiwy Yasmine

机构信息

a Department of Clinical & Chemical Pathology , Faculty of Medicine, Cairo University , Cairo , Egypt.

b Department of Surgical Oncology , National Cancer Institute, Cairo Univeristy , Cairo , Egypt.

出版信息

Cancer Invest. 2017 Feb 7;35(2):71-77. doi: 10.1080/07357907.2016.1247454. Epub 2017 Jan 17.

DOI:10.1080/07357907.2016.1247454

PMID:28095066

Abstract

We investigated the association of the Osteopontin (OPN) (rs9138 and rs1126616) polymorphisms with colorectal cancer (CRC). One hundred CRC patients and 112 healthy individuals were subjected to OPN (rs9138 and rs1126616) genotyping and measurement of OPN protein plasma level. The C allele of OPN rs1126616 and the CC haplotype were significantly higher in CRC patient (p = 0.036, 0.003, respectively). In females, the C allele of OPN rs9318 (A/C) polymorphism was significantly associated with increased CRC risk (p = 0.036). The plasma OPN level >104.35 ng/mL was significantly associated with CRC. Our findings suggest a significant role played by OPN (rs9138 and rs1126616) in colorectal carcinogenesis.

摘要

我们研究了骨桥蛋白（OPN）（rs9138和rs1126616）基因多态性与结直肠癌（CRC）的关联。对100例CRC患者和112名健康个体进行了OPN（rs9138和rs1126616）基因分型及OPN蛋白血浆水平检测。CRC患者中OPN rs1126616的C等位基因及CC单倍型显著更高（分别为p = 0.036、0.003）。在女性中，OPN rs9318（A/C）多态性的C等位基因与CRC风险增加显著相关（p = 0.036）。血浆OPN水平>104.35 ng/mL与CRC显著相关。我们的研究结果表明OPN（rs9138和rs1126616）在结直肠癌发生过程中发挥了重要作用。