Wiegand Cornelia, Reddersen Kirsten, Hipler Uta-Christina, Abel Martin, Ruth Peter, Andriessen Anneke
Department of Dermatology, University Hospital Jena, Jena, Germany.
Skin Pharmacol Physiol. 2016;29(6):318-323. doi: 10.1159/000454720. Epub 2017 Jan 18.
Removal of nonvital tissue is an accepted method to eradicate biofilms and to stimulate wound healing. Debridement using a monofilament polyester fiber pad has clinically been shown to be effective as well as pain and trauma free.
For in vitro determination of the cleansing capacity of this product compared to gauze swabs, a wound debridement model was used with glass plates coated with a bovine serum albumin solution, stained with hematoxylin. Both products were moistened and fixed to a weight connected to a regulated motor and were then pulled over the holding device with the coated glass plate under standardized conditions (power = 0.067 N/cm2, velocity = 1.6 cm/s).
At a low coating concentration (0.5%) both products were equally effective, but at a high concentration (1.5%) cleansing did not occur after 5 wipes. When wiping the plates 15 times, the debridement pad cleansed significantly (p < 0.001) better than gauze. When consecutively wiping 4 coated plates with a single debridement pad or swab, the pad exhibited and maintained a significantly higher cleansing capacity while gauze quickly lost its effect.
Our in vitro test results indicated a higher cleansing capacity of the debridement pad compared to gauze swabs.
去除失活组织是根除生物膜和促进伤口愈合的一种公认方法。临床上已证明,使用单丝聚酯纤维垫进行清创术既有效,又无痛且无创伤。
为了在体外测定该产品与纱布拭子相比的清洁能力,使用了一个伤口清创模型,该模型采用涂有牛血清白蛋白溶液并用苏木精染色的玻璃板。将两种产品浸湿后固定在与调节电机相连的重物上,然后在标准化条件下(功率 = 0.067 N/cm²,速度 = 1.6 cm/s),将其拉过装有涂层玻璃板的固定装置。
在低涂层浓度(0.5%)下,两种产品的效果相同,但在高浓度(1.5%)下,擦拭5次后未发生清洁作用。当擦拭玻璃板15次时,清创垫的清创效果明显优于纱布(p < 0.001)。当用单个清创垫或拭子连续擦拭4个涂有涂层的玻璃板时,清创垫表现出并保持了明显更高的清洁能力,而纱布的效果很快就消失了。
我们的体外测试结果表明,与纱布拭子相比,清创垫具有更高的清洁能力。