Del Rosso James Q, Kircik Leon H
J Drugs Dermatol. 2017 Jan 1;16(1):s4-s10.
Nitric oxide (NO) is a diatomic gas that is synthesized within and released by multiple host cell types functioning to provide a variety of physiologic and homeostatic effects. Nitric oxide exhibits a variety of effects that relate significantly with outcomes that can provide therapeutic benefit if properly formulated and released. These include anti-inflammatory, immunomodulatory, antimicrobial, vasodilatory properties, and effects that are beneficial to wound healing. Lack of antibiotic resistance appears to be one major advantage of topically delivered NO. A specific topical formulation of NO has been developed that has been shown thus far in clinical studies to exhibit favorable efficacy and safety. This article provides a thorough review of the biologic effects of NO, discusses modes of action and potential pharmacologic benefits, and reviews currently available clinical data for acne. J Drugs Dermatol. 2017;16(1 Suppl 1):s4-10.
一氧化氮（NO）是一种双原子气体，由多种宿主细胞类型合成并释放，发挥多种生理和稳态作用。一氧化氮具有多种效应，这些效应与结果密切相关，如果能正确配制和释放，可带来治疗益处。这些效应包括抗炎、免疫调节、抗菌、血管舒张特性以及对伤口愈合有益的作用。局部递送一氧化氮的一个主要优势似乎是不存在抗生素耐药性。目前已开发出一种一氧化氮的特定局部制剂，迄今为止的临床研究表明其具有良好的疗效和安全性。本文全面综述了一氧化氮的生物学效应，讨论了其作用方式和潜在的药理学益处，并回顾了目前关于痤疮的临床数据。《药物皮肤病学杂志》。2017年；16(1增刊1):s4 - 10。
