Clinique de Dermatologie, Allergologie et Photobiologie, CHU A Michallon, Grenoble, France.
Hôpital Européen Georges Pompidou, Paris, France.
J Eur Acad Dermatol Venereol. 2015 Aug;29(8):1485-92. doi: 10.1111/jdv.12989. Epub 2015 Feb 10.
Acne vulgaris (acne) is a chronic inflammatory disease of the sebaceous gland, characterized by follicular hyperkeratinization, excessive colonization by Propionibacterium acnes (P. acnes) as well as immune reactions and inflammation. Despite an armamentarium of topical treatments available including benzoyl peroxide, retinoids and azelaic acid, topical antibiotics in monotherapies, especially erythromycin and clindamycin, are still used in Europe to treat acne. This intensive use led to antimicrobial-resistant P. acnes and staphylococci strains becoming one of the main health issues worldwide. This is an update on the current topical acne treatments available in Europe, their mechanism of action, their potential to induce antimicrobial resistance and their clinical efficacy and safety.
寻常痤疮（痤疮）是一种皮脂腺的慢性炎症性疾病，其特征是滤泡过度角化、痤疮丙酸杆菌（P. acnes）过度定植以及免疫反应和炎症。尽管有一系列局部治疗方法，包括过氧化苯甲酰、类视黄醇和壬二酸，但在欧洲，局部抗生素（包括红霉素和克林霉素）仍单独用于治疗痤疮。这种大量使用导致了具有抗药性的痤疮丙酸杆菌和葡萄球菌菌株成为全球主要的健康问题之一。本文就欧洲目前可用于治疗痤疮的局部治疗方法进行了更新，包括其作用机制、诱导抗药性的潜力以及临床疗效和安全性。
