Stehle J, Vanecek J, Vollrath L
Department of Anatomy, University of Mainz, Federal Republic of Germany.
J Neural Transm. 1989;78(2):173-7. doi: 10.1007/BF01252503.
Circadian rhythms, endogenously generated in suprachiasmatic nuclei (SCN), seem to be under the direct influence of melatonin. Therefore, the effect of iontophoretically applied melatonin on electrical activity of SCN neurons was investigated in vitro. Usually, melatonin had an inhibitory effect. In the 3-h periods before (2.00-5.00 p.m.) or after (5.00-8.00 p.m.) the light-dark transition the percentage of SCN neurons sensitive to melatonin was very high (80% and 100%, respectively). However, efficacy of melatonin was low in the periods preceeding (20%) and following (33%) this 6-h time interval.
昼夜节律由视交叉上核（SCN）内源性产生，似乎受到褪黑素的直接影响。因此，在体外研究了离子导入褪黑素对视交叉上核神经元电活动的影响。通常，褪黑素具有抑制作用。在明暗转换前（下午2点至5点）或后（下午5点至8点）的3小时时间段内，对视交叉上核褪黑素敏感的神经元百分比非常高（分别为80%和100%）。然而，在这个6小时时间间隔之前（20%）和之后（33%）的时间段内，褪黑素的效力较低。
