Owino Sharon, Buonfiglio Daniella D C, Tchio Cynthia, Tosini Gianluca
Department of Pharmacology and Toxicology Morehouse School of Medicine, Neuroscience Institute, Atlanta, GA, United States.
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, United States.
Front Endocrinol (Lausanne). 2019 Jul 17;10:488. doi: 10.3389/fendo.2019.00488. eCollection 2019.
Melatonin, a hormone synthesized by both the pineal gland and retina, functions as an important modulator of a number of physiological functions. In addition to its rather well-established roles in the regulation of circadian rhythms, sleep, and reproduction, melatonin has also been identified as an important regulator of glucose metabolism. Recent genomic studies have also shown that disruption of melatonin receptors signaling may contribute to the pathogenesis of type 2 diabetes, although the exact mechanisms underlying its action remain unclear. Additionally, a large number of animal studies have highlighted a role for melatonin in the regulation of both glucose metabolism and energy balance. This review summarizes the current knowledge on the role that melatonin and its associated receptors play in the regulation of metabolism.
褪黑素是一种由松果体和视网膜合成的激素，作为多种生理功能的重要调节因子发挥作用。除了在昼夜节律、睡眠和生殖调节方面已确立的作用外，褪黑素还被确定为葡萄糖代谢的重要调节因子。最近的基因组研究还表明，褪黑素受体信号传导的破坏可能导致2型糖尿病的发病机制，尽管其作用的确切机制仍不清楚。此外，大量动物研究强调了褪黑素在葡萄糖代谢和能量平衡调节中的作用。本综述总结了目前关于褪黑素及其相关受体在代谢调节中作用的知识。
