Lythgoe Hanna, Price Victoria, Poustie Vanessa, Attar Sabah, Hawcutt Daniel, Preston Jennifer, Beresford Michael W
Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
NIHR Alder Hey Clinical Research Facility, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Arch Dis Child. 2017 Aug;102(8):755-759. doi: 10.1136/archdischild-2016-311057. Epub 2017 Jan 17.
This review provides paediatricians with an update on the new structure of the National Institute for Health Research's (NIHR) Clinical Research Network (CRN): Children and its role within the wider NIHR infrastructure. The network supports delivery of high-quality research within the NHS in England and supports researchers, through provision of staff and resources, with feasibility, site set-up, patient recruitment and study management. Since 2013, over 80% of commercial contract studies running within the UK sat within the UKCRN Portfolio. Of the diverse, increasing portfolio of studies supported by the network, many studies are interventional, with 33% being randomised controlled studies. Recruitment to studies supported by the network through the Children's Portfolio has consistently improved. Over 200 000 participants have been recruited to the Children's Portfolio studies to date, and there are currently approximately 500 studies open to recruitment. The CRN: Children has successfully involved patients and the public in all aspects of study design and delivery, including through the work of Generation R. Challenges remain in conducting paediatric research and the network is committed to supporting Children's research and further building on its achievements to date. Education and engagement of paediatricians within the network and research is important to further improving quality and delivery of paediatric research.
本综述为儿科医生提供了关于英国国家卫生研究院（NIHR）临床研究网络（CRN）：儿童的新结构及其在更广泛的NIHR基础设施中的作用的最新信息。该网络支持在英格兰国民保健服务体系（NHS）内开展高质量研究，并通过提供人员和资源，在可行性、研究点设立、患者招募和研究管理等方面为研究人员提供支持。自2013年以来，在英国开展的超过80%的商业合同研究都在英国临床研究网络（UKCRN）项目组合范围内。在该网络支持的多样化且不断增加的研究项目组合中，许多研究是干预性的，其中33%是随机对照试验。通过儿童项目组合，由该网络支持的研究的招募情况一直在改善。迄今为止，已有超过20万名参与者被招募到儿童项目组合研究中，目前大约有500项研究正在招募患者。CRN：儿童已成功让患者和公众参与到研究设计和实施的各个方面，包括通过“R世代”的工作。开展儿科研究仍存在挑战，该网络致力于支持儿童研究，并在其迄今取得的成就基础上进一步发展。网络内儿科医生的教育和参与以及研究对于进一步提高儿科研究的质量和实施至关重要。
