Wolverhampton Eye Infirmary, The Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK.
Manchester Royal Eye Hospital, Manchester, UK.
Eye (Lond). 2019 Apr;33(4):610-618. doi: 10.1038/s41433-018-0251-8. Epub 2018 Nov 20.
To report on the composition and performance of the portfolio of Ophthalmology research studies in the United Kingdom's National Institute for Health Research (NIHR) Clinical Research Network (UK CRN).
Ophthalmology studies open to recruitment between 1 April 2010 and 31 March 2018 were classified by: sub-specialty, participant age, gender of Chief Investigator, involvement of genetic investigations, commercial/ non-commercial, interventional/observational design. Frequency distributions for each covariate and temporal variation in recruitment to time and target were analysed.
Over 8 years, 137,377 participants were recruited (average of 15,457 participants/year; range: 5485-32,573) with growth by year in proportion of commercial studies and hospital participation in England (76% in 2017/18). Fourteen percent of studies had a genetic component and most studies (82%) included only adults. The majority of studies (41%) enrolled patients with retinal diseases, followed by glaucoma (17%), anterior segment and cataract (13%), and ocular inflammation (6%). Overall, 68% of non-commercial studies and 55% of commercial studies recruited within the anticipated time set by the study and also recruited to or exceeded the target number of participants.
High levels of clinical research activity, growth and improved performance have been observed in Ophthalmology in UK over the past 8 years. Some sub-specialties that carry substantial morbidity and a very high burden on NHS services are underrepresented and deserve more patient-centred research. Yet the NIHR and its CRN Ophthalmology National Specialty Group has enabled key steps in achieving the goal of embedding research into every day clinical care.
报告英国国民健康研究所（NIHR）临床研究网络（英国 CRN）中眼科研究组合的构成和表现。
将 2010 年 4 月 1 日至 2018 年 3 月 31 日期间开放招募的眼科研究按亚专科、参与者年龄、首席研究员的性别、遗传研究的参与情况、商业/非商业、干预/观察性设计进行分类。对每个协变量的频率分布以及对时间和目标的招募进行时间变化分析。
8 年来，共招募了 137377 名参与者（平均每年 15457 名参与者；范围：5485-32573），2017/18 年商业研究和英格兰医院参与的比例逐年增长。14%的研究具有遗传成分，大多数研究（82%）仅包括成年人。大多数研究（41%）招募了视网膜疾病患者，其次是青光眼（17%）、前节和白内障（13%）和眼部炎症（6%）。总体而言，68%的非商业研究和 55%的商业研究在研究设定的预期时间内招募到了预期数量的参与者，并且招募到的参与者数量超过了目标数量。
在过去的 8 年中，英国眼科的临床研究活动、增长和表现都有了显著提高。一些亚专科存在大量发病率和对国民保健服务系统的极高负担，代表性不足，需要更多以患者为中心的研究。然而，NIHR 及其 CRN 眼科国家专业组已经在将研究嵌入日常临床护理的目标方面迈出了关键的一步。
