染色质结构域解旋酶DNA结合染色质重塑因子：预防和促进癌症的家族特征
The Chromodomain Helicase DNA-Binding Chromatin Remodelers: Family Traits that Protect from and Promote Cancer.
作者信息
Mills Alea A
机构信息
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 11724.
出版信息
Cold Spring Harb Perspect Med. 2017 Apr 3;7(4):a026450. doi: 10.1101/cshperspect.a026450.
Abstract
A plethora of mutations in chromatin regulators in diverse human cancers is emerging, attesting to the pivotal role of chromatin dynamics in tumorigenesis. A recurrent theme is inactivation of the chromodomain helicase DNA-binding (CHD) family of proteins-ATP-dependent chromatin remodelers that govern the cellular machinery's access to DNA, thereby controlling fundamental processes, including transcription, proliferation, and DNA damage repair. This review highlights what is currently known about how genetic and epigenetic perturbation of CHD proteins and the pathways that they regulate set the stage for cancer, providing new insight for designing more effective anti-cancer therapies.
摘要
各种人类癌症中染色质调节因子的大量突变不断出现，这证明了染色质动力学在肿瘤发生中的关键作用。一个反复出现的主题是染色质结构域解旋酶DNA结合（CHD）蛋白家族失活，CHD蛋白是依赖ATP的染色质重塑因子，控制细胞机制对DNA的访问，从而控制包括转录、增殖和DNA损伤修复在内的基本过程。本综述重点介绍了目前已知的CHD蛋白的遗传和表观遗传扰动以及它们所调节的信号通路如何为癌症的发生奠定基础，为设计更有效的抗癌疗法提供了新的见解。
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