在退行性瓣膜疾病中静脉注射幼犬乳牙干细胞。
Intravenous administration of puppy deciduous teeth stem cells in degenerative valve disease.
作者信息
Petchdee Soontaree, Sompeewong Sarunya
机构信息
Department of Large Animal and Wildlife Clinical Science, Faculty of Veterinary Medicine, Kasetsart University, Kamphaengsaen, Nakhorn Pathom 73140, Thailand.
Kasetsart University, Veterinary Teaching Animal Hospital, Kamphaeng Saen, Thailand.
出版信息
Vet World. 2016 Dec;9(12):1429-1434. doi: 10.14202/vetworld.2016.1429-1434. Epub 2016 Dec 16.
AIM
The objective of this study is to investigate the improvement of heart function in dogs with chronic valvular heart disease after puppy deciduous teeth stem cells (pDSCs) administration.
MATERIALS AND METHODS
20 client-owned dogs with degenerative valvular heart disease underwent multiple intravenous injections of allogeneic pDSCs. Dogs were randomly assigned to two groups: (i) Control group (n=10) with standard treatment for heart failure and (ii) group with standard treatment and multiple administrations of pDSCs (n=10). Electrocardiography, complete transthoracic echocardiography, thoracic radiography, and blood pressure were recorded before and after pDSCs injections for 15, 30 and 60 days.
RESULTS
Post pDSCs injection showed measurable improvement in left ventricular ejection fraction, American College of Veterinary Internal Medicine (ACVIM) functional class significantly improved and improved quality of life scores were observed. In the control group, there were no significant enhancements in heart function or ACVIM class.
CONCLUSIONS
This finding suggests that pDSCs could be a supplement for valvular heart disease treatment.
目的
本研究的目的是调查给患有慢性瓣膜性心脏病的犬注射幼犬乳牙干细胞（pDSCs）后心脏功能的改善情况。
材料与方法
20只患有退行性瓣膜性心脏病的客户拥有的犬接受了多次同种异体pDSCs静脉注射。犬被随机分为两组：（i）接受心力衰竭标准治疗的对照组（n = 10）和（ii）接受标准治疗并多次注射pDSCs的组（n = 10）。在注射pDSCs前以及注射后15、30和60天记录心电图、完整的经胸超声心动图、胸部X线摄影和血压。
结果
注射pDSCs后左心室射血分数有可测量的改善，美国兽医内科学会（ACVIM）功能分级显著改善，并且观察到生活质量评分提高。在对照组中，心脏功能或ACVIM分级没有显著增强。
结论
这一发现表明pDSCs可能是瓣膜性心脏病治疗的一种补充手段。
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