• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

透明质霉素，一种新型透明质酸酶抑制剂，可减弱胰腺癌细胞的迁移和增殖。

Hyaluromycin, a Novel Hyaluronidase Inhibitor, Attenuates Pancreatic Cancer Cell Migration and Proliferation.

作者信息

Kohi Shiro, Sato Norihiro, Koga Atsuhiro, Hirata Keiji, Harunari Enjuro, Igarashi Yasuhiro

机构信息

Department of Surgery 1, University of Occupational and Environmental Health, Kitakyushu, Japan.

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

出版信息

J Oncol. 2016;2016:9063087. doi: 10.1155/2016/9063087. Epub 2016 Dec 20.

DOI:10.1155/2016/9063087
PMID:28096814
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5206452/
Abstract

Pancreatic ductal adenocarcinoma (PDAC) is characterized by accelerated production and degradation of hyaluronan (HA), a major component of extracellular matrix involved in the malignant phenotype of cancer. In particular, increased hyaluronidase (HYAL) activity plays a critical role in cancer progression, at least in part, by producing low-molecular-weight- (LMW-) HA or small fragments of HA, suggesting HYAL as a target for cancer treatment. Hyaluromycin, a new member of the rubromycin family of antibiotics, was isolated from the culture extract of a marine-derived as a HYAL inhibitor. We investigated the antitumor effects of hyaluromycin in PDAC cells. We examined the effects of hyaluromycin on the proliferation and migration of PDAC cells. To elucidate the mechanisms underlying the effect of hyaluromycin on PDAC cells, we examined the concentration of LMW-HA in the conditioned media after treating PDAC cells with hyaluromycin. We demonstrate that hyaluromycin inhibits proliferation and migration of PDAC cells. We also found that these antitumor effects of hyaluromycin were associated with a decreased concentration of LMW-HA and a decreased phosphorylation of ribosomal protein S6. Our results suggest that hyaluromycin is a promising new drug against this highly aggressive neoplasm.

摘要

胰腺导管腺癌（PDAC）的特征是透明质酸（HA）的产生和降解加速，HA是参与癌症恶性表型的细胞外基质的主要成分。特别是，透明质酸酶（HYAL）活性增加在癌症进展中起关键作用，至少部分是通过产生低分子量（LMW）-HA或HA的小片段，这表明HYAL可作为癌症治疗的靶点。海洛霉素是一种新的红霉素类抗生素，从海洋来源的培养提取物中分离出来作为HYAL抑制剂。我们研究了海洛霉素对PDAC细胞的抗肿瘤作用。我们检测了海洛霉素对PDAC细胞增殖和迁移的影响。为了阐明海洛霉素对PDAC细胞作用的潜在机制，我们检测了用海洛霉素处理PDAC细胞后条件培养基中LMW-HA的浓度。我们证明海洛霉素抑制PDAC细胞的增殖和迁移。我们还发现海洛霉素的这些抗肿瘤作用与LMW-HA浓度降低和核糖体蛋白S6磷酸化降低有关。我们的结果表明海洛霉素是一种有前景的针对这种高度侵袭性肿瘤的新药。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c00d/5206452/3e343cc5ad7d/JO2016-9063087.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c00d/5206452/f28ae773ad45/JO2016-9063087.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c00d/5206452/0747493972fc/JO2016-9063087.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c00d/5206452/e279dd1c4d04/JO2016-9063087.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c00d/5206452/3e343cc5ad7d/JO2016-9063087.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c00d/5206452/f28ae773ad45/JO2016-9063087.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c00d/5206452/0747493972fc/JO2016-9063087.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c00d/5206452/e279dd1c4d04/JO2016-9063087.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c00d/5206452/3e343cc5ad7d/JO2016-9063087.004.jpg

相似文献

1
Hyaluromycin, a Novel Hyaluronidase Inhibitor, Attenuates Pancreatic Cancer Cell Migration and Proliferation.透明质霉素，一种新型透明质酸酶抑制剂，可减弱胰腺癌细胞的迁移和增殖。
J Oncol. 2016;2016:9063087. doi: 10.1155/2016/9063087. Epub 2016 Dec 20.
2
Hyaluromycin, a new hyaluronidase inhibitor of polyketide origin from marine Streptomyces sp.透明质霉素，一种源自海洋链霉菌属的新型聚酮类透明质酸酶抑制剂
Mar Drugs. 2014 Jan 21;12(1):491-507. doi: 10.3390/md12010491.
3
KIAA1199 is induced by inflammation and enhances malignant phenotype in pancreatic cancer.KIAA1199由炎症诱导，并增强胰腺癌的恶性表型。
Oncotarget. 2017 Mar 7;8(10):17156-17163. doi: 10.18632/oncotarget.15052.
4
Hyaluronan stimulates pancreatic cancer cell motility.透明质酸刺激胰腺癌细胞的运动性。
Oncotarget. 2016 Jan 26;7(4):4829-40. doi: 10.18632/oncotarget.6617.
5
Draft genome sequence of MB-PO13, a hyaluromycin producer.透明质霉素产生菌MB-PO13的基因组序列草图
Stand Genomic Sci. 2018 Jan 11;13:2. doi: 10.1186/s40793-017-0286-7. eCollection 2018.
6
Hyaluronan activated-metabolism phenotype (HAMP) in pancreatic ductal adenocarcinoma.胰腺导管腺癌中的透明质酸激活代谢表型（HAMP）
Oncotarget. 2019 Sep 24;10(54):5592-5604. doi: 10.18632/oncotarget.27172.
7
Increased Expression of HYAL1 in Pancreatic Ductal Adenocarcinoma.透明质酸酶1（HYAL1）在胰腺导管腺癌中的表达增加
Pancreas. 2016 Nov;45(10):1467-1473. doi: 10.1097/MPA.0000000000000670.
8
A novel role of low molecular weight hyaluronan in breast cancer metastasis.低分子量透明质酸在乳腺癌转移中的新作用。
FASEB J. 2015 Apr;29(4):1290-8. doi: 10.1096/fj.14-259978. Epub 2014 Dec 30.
9
A novel epigenetic mechanism regulating hyaluronan production in pancreatic cancer cells.一种调节胰腺癌细胞中透明质酸生成的新型表观遗传机制。
Clin Exp Metastasis. 2016 Mar;33(3):225-30. doi: 10.1007/s10585-015-9771-9. Epub 2015 Nov 20.
10
Negative regulation between the expression levels of receptor for hyaluronic acid-mediated motility and hyaluronan leads to cell migration in pancreatic cancer.透明质酸介导的运动受体与透明质酸表达水平之间的负调控导致胰腺癌中的细胞迁移。
Oncol Lett. 2020 Nov;20(5):199. doi: 10.3892/ol.2020.12060. Epub 2020 Sep 4.

引用本文的文献

1
Lutein derived from Xenostegia tridentata exhibits anticancer activities against A549 lung cancer cells via hyaluronidase inhibition.从三裂叶薯中提取的叶黄素通过抑制透明质酸酶对A549肺癌细胞具有抗癌活性。
PLoS One. 2024 Dec 16;19(12):e0315570. doi: 10.1371/journal.pone.0315570. eCollection 2024.
2
Targeting BET Proteins Decreases Hyaluronidase-1 in Pancreatic Cancer.靶向 BET 蛋白可降低胰腺癌中的透明质酸酶-1。
Cells. 2023 May 27;12(11):1490. doi: 10.3390/cells12111490.
3
Development of a drug discovery approach from microbes with a special focus on isolation sources and taxonomy.

本文引用的文献

1
Increased Expression of HYAL1 in Pancreatic Ductal Adenocarcinoma.透明质酸酶1（HYAL1）在胰腺导管腺癌中的表达增加
Pancreas. 2016 Nov;45(10):1467-1473. doi: 10.1097/MPA.0000000000000670.
2
Hyaluronan stimulates pancreatic cancer cell motility.透明质酸刺激胰腺癌细胞的运动性。
Oncotarget. 2016 Jan 26;7(4):4829-40. doi: 10.18632/oncotarget.6617.
3
Hyperphosphorylation of ribosomal protein S6 predicts unfavorable clinical survival in non-small cell lung cancer.核糖体蛋白S6的过度磷酸化预示非小细胞肺癌患者的临床预后不良。
从微生物中开发药物发现方法，特别关注分离源和分类学。
J Antibiot (Tokyo). 2023 Jul;76(7):365-383. doi: 10.1038/s41429-023-00625-y. Epub 2023 May 15.
4
Strategies for Glycoengineering Therapeutic Proteins.糖基工程改造治疗性蛋白质的策略
Front Chem. 2022 Apr 13;10:863118. doi: 10.3389/fchem.2022.863118. eCollection 2022.
5
Neomenthol prevents the proliferation of skin cancer cells by restraining tubulin polymerization and hyaluronidase activity.新薄荷醇通过抑制微管蛋白聚合和透明质酸酶活性来阻止皮肤癌细胞的增殖。
J Adv Res. 2021 Jun 10;34:93-107. doi: 10.1016/j.jare.2021.06.003. eCollection 2021 Dec.
6
Matters of size: Roles of hyaluronan in CNS aging and disease.大小问题：透明质酸在中枢神经系统衰老和疾病中的作用。
Ageing Res Rev. 2021 Dec;72:101485. doi: 10.1016/j.arr.2021.101485. Epub 2021 Oct 9.
7
Antioxidant, Anti-Inflammatory, and Cytotoxic Activity of Extracts from Some Commercial Apple Cultivars in Two Colorectal and Glioblastoma Human Cell Lines.某些商业苹果品种提取物在两种人结肠直肠癌和胶质母细胞瘤细胞系中的抗氧化、抗炎及细胞毒性活性
Antioxidants (Basel). 2021 Jul 8;10(7):1098. doi: 10.3390/antiox10071098.
8
Improved Surface Display of Human Hyal1 and Identification of Testosterone Propionate and Chicoric Acid as New Inhibitors.人Hyal1的表面展示改善及丙酸睾酮和菊苣酸作为新型抑制剂的鉴定
Pharmaceuticals (Basel). 2020 Mar 26;13(4):54. doi: 10.3390/ph13040054.
9
Hyaluronan activated-metabolism phenotype (HAMP) in pancreatic ductal adenocarcinoma.胰腺导管腺癌中的透明质酸激活代谢表型（HAMP）
Oncotarget. 2019 Sep 24;10(54):5592-5604. doi: 10.18632/oncotarget.27172.
10
Novel discoveries targeting gemcitabine-based chemoresistance and new therapies in pancreatic cancer: How far are we from the destination?针对吉西他滨耐药的新发现和胰腺癌的新疗法：我们离目标还有多远？
Cancer Med. 2019 Oct;8(14):6403-6413. doi: 10.1002/cam4.2384. Epub 2019 Sep 1.
J Exp Clin Cancer Res. 2015 Oct 21;34:126. doi: 10.1186/s13046-015-0239-1.
4
Glycyrrhizic acid inhibits leukemia cell growth and migration via blocking AKT/mTOR/STAT3 signaling.甘草酸通过阻断AKT/mTOR/STAT3信号通路抑制白血病细胞的生长和迁移。
Int J Clin Exp Pathol. 2015 May 1;8(5):5175-81. eCollection 2015.
5
A novel role of low molecular weight hyaluronan in breast cancer metastasis.低分子量透明质酸在乳腺癌转移中的新作用。
FASEB J. 2015 Apr;29(4):1290-8. doi: 10.1096/fj.14-259978. Epub 2014 Dec 30.
6
Emerging roles for hyaluronidase in cancer metastasis and therapy.透明质酸酶在癌症转移和治疗中的新作用。
Adv Cancer Res. 2014;123:1-34. doi: 10.1016/B978-0-12-800092-2.00001-0.
7
Hyaluromycin, a new hyaluronidase inhibitor of polyketide origin from marine Streptomyces sp.透明质霉素，一种源自海洋链霉菌属的新型聚酮类透明质酸酶抑制剂
Mar Drugs. 2014 Jan 21;12(1):491-507. doi: 10.3390/md12010491.
8
Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis.HYAL1 表达上调促进乳腺癌肿瘤细胞增殖、迁移、侵袭和血管生成。
PLoS One. 2011;6(7):e22836. doi: 10.1371/journal.pone.0022836. Epub 2011 Jul 28.
9
Targeting hyaluronidase for cancer therapy: antitumor activity of sulfated hyaluronic acid in prostate cancer cells.靶向透明质酸酶治疗癌症：硫酸透明质酸对前列腺癌细胞的抗肿瘤活性。
Cancer Res. 2011 Jun 15;71(12):4085-95. doi: 10.1158/0008-5472.CAN-10-4610. Epub 2011 May 9.
10
Comparison of hyaluronidase expression, invasiveness and tubule formation promotion in ER (-) and ER (+) breast cancer cell lines in vitro.体外比较ER（-）和ER（+）乳腺癌细胞系中透明质酸酶的表达、侵袭性及促进小管形成的能力。
Chin Med J (Engl). 2009 Jun 5;122(11):1300-4.