Kim Tae Heon, Kim Chan Kyo, Park Byung Kwan, Jeon Hwang Gyun, Jeong Byung Chang, Seo Seong Il, Lee Hyun Moo, Choi Han Yong, Jeon Seong Soo
Department of Urology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
Department of Radiology, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Korea.
Can Urol Assoc J. 2016 Nov-Dec;10(11-12):E377-E382. doi: 10.5489/cuaj.3896. Epub 2016 Nov 10.
We assessed the correlation between the apparent diffusion coefficient (ADC) and pathological Gleason score (GS) of prostate cancer patients.
A total of 125 patients who underwent multiparametric magnetic resonance imaging before radical prostatectomy for prostate cancer were included in this study. ADC values were compared with different GS. We used receiver operating characteristic analysis and determined the ADC cutoff value to differentiate tumours with a GS of 6 from those with a GS ≥7.
We identified 34 patients (27.2%) with a GS of 6; 33 patients (26.4%) with a GS of 7; 22 patients (17.6%) with a GS of 8; and 36 patients (28.8%) with a GS of ≥9. The mean ADC value for disease with a GS of 6 was 0.914 ± 0.161 ×10 mm/s; GS of 7: 0.741 ± 0.164 ×10 mm/s; GS of 8: 0.679 ± 0.130 ×10 mm/s; and GS of ≥9: 0.593 ± 0.089 ×10 mm/s. An ADC value of 0.830 ×10mm/s was the best cutoff value to identify prostate cancer with a GS of 6.
We observed an inverse relationship between GS and ADC value. Moreover, a cutoff ADC value may help differentiate disease with a GS of 6 from disease with a GS ≥7.
我们评估了前列腺癌患者的表观扩散系数（ADC）与病理Gleason评分（GS）之间的相关性。
本研究纳入了125例在前列腺癌根治性前列腺切除术前行多参数磁共振成像的患者。将ADC值与不同的GS进行比较。我们采用受试者工作特征分析，并确定了ADC临界值，以区分GS为6的肿瘤与GS≥7的肿瘤。
我们确定了34例（27.2%）GS为6的患者；33例（26.4%）GS为7的患者；22例（17.6%）GS为8的患者；以及36例（28.8%）GS≥9的患者。GS为6的疾病的平均ADC值为0.914±0.161×10⁻³mm²/s；GS为7的疾病：0.741±0.164×10⁻³mm²/s；GS为8的疾病：0.679±0.130×10⁻³mm²/s；GS≥9的疾病：0.593±0.089×10⁻³mm²/s。ADC值为0.830×10⁻³mm²/s是识别GS为6的前列腺癌的最佳临界值。
我们观察到GS与ADC值之间呈负相关。此外，ADC临界值可能有助于区分GS为6的疾病与GS≥7的疾病。
