Gagné Andréanne, Sazonova Olga, Marceau Simon, Périgny Martine, Joubert Philippe
Department of Pathology, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec City, QC, Canada.
Department of Bariatric Surgery, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec City, QC, Canada.
Case Rep Pathol. 2016;2016:1537240. doi: 10.1155/2016/1537240. Epub 2016 Dec 21.
. Duplication cysts are rare benign lesions usually arising in the gastrointestinal tract. We report a case of a 52-year-old woman with an incidental gastric mass found on computed tomography during a pregraft workup for a familial cardiomyopathy. . The mass was completely excised by partial gastrectomy and gross examination revealed a cystic lesion containing two small solid nodules in its wall. Microscopic evaluation and immunohistochemistry study were performed to further characterize the cyst and the nodules. A comprehensive literature review of the NCBI database PubMed was also carried out. . While the cyst was diagnosed as a foregut duplication cyst, the solid nodules proved to be concomitant gastrointestinal stromal tumor (GIST) and leiomyoma. Both morphologic features and immunohistochemistry stains, including CD117, smooth muscle actin, and CD34 supported the diagnosis. Clinical course was benign and the patient had no clinical evidence of relapse ten months following the surgical procedure. The literature search did not reveal any other published case of a foregut duplication cyst presenting in combination with a GIST and a leiomyoma. . To our knowledge, this is the first case of a composite lesion comprising a foregut duplication cyst of the stomach along with a leiomyoma and a GIST.
重复囊肿是罕见的良性病变，通常发生于胃肠道。我们报告一例52岁女性，在因家族性心肌病进行移植前检查的计算机断层扫描时偶然发现胃内肿物。该肿物通过部分胃切除术被完整切除，大体检查显示为一个囊性病变，其壁内有两个小的实性结节。进行了显微镜评估和免疫组织化学研究以进一步明确囊肿和结节的特征。还对NCBI数据库PubMed进行了全面的文献综述。虽然囊肿被诊断为前肠重复囊肿，但实性结节被证实为同时存在的胃肠道间质瘤（GIST）和平滑肌瘤。形态学特征及免疫组织化学染色，包括CD117、平滑肌肌动蛋白和CD34均支持该诊断。临床病程呈良性，患者在手术十个月后无复发的临床证据。文献检索未发现其他前肠重复囊肿合并GIST和平滑肌瘤的病例报道。据我们所知，这是首例由胃前肠重复囊肿以及平滑肌瘤和GIST组成的复合病变。
