Sali Shahnaz, Tavakolpour Soheil, Farkhondemehr Baharan
Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Clin Transl Hepatol. 2016 Dec 28;4(4):306-309. doi: 10.14218/JCTH.2016.00037. Epub 2016 Dec 27.
During recent years, the relationship between vitamin D levels and chronic hepatitis B (CHB) infection has attracted many researchers' attention. However, the results relating to the association of vitamin D levels and HBV infection have been conflicting and there remains a lack of knowledge about the effects of antiviral treatments on vitamin D level. Eighty-four patients with CHB were assessed and divided into three groups: inactive carriers ( = 28), treated ( = 34), and new (treatment-naïve) cases ( = 22). Thirty-two healthy controls (HCs) were included to enable comparison with the CHB groups. The levels of vitamin D3 were measured and statistically compared among the various groups. Male subjects had higher levels of vitamin D3 (41.25 28.85, < 0.01). No association was found among any of the groups when compared with the HC group. Despite the significant association, the HCs demonstrated a higher level of vitamin D3, which was lower in the treated group, the inactive carrier group, and the new cases group (new case [29.82] < inactive carrier [32.91] < treated [39.56] < control [44.88]). The HBV DNA levels were not associated with vitamin D3 levels in the inactive carriers ( = 0.171), the treated groups ( = 0.192), and the new cases ( = 0.369). Moreover, the alanine transaminase and aspartate transaminase levels were not associated with vitamin D3 levels for any of the HBV-infected groups. Vitamin D3 contributes to the clinical statues of CHB patients. There is also a possible correlation between clinically healthy CHB patients and vitamin D3 level.
近年来，维生素D水平与慢性乙型肝炎（CHB）感染之间的关系引起了众多研究者的关注。然而，关于维生素D水平与HBV感染之间关联的研究结果一直存在争议，并且对于抗病毒治疗对维生素D水平的影响仍缺乏了解。对84例CHB患者进行了评估，并将其分为三组：非活动性携带者（n = 28）、接受治疗者（n = 34）和新发病例（初治患者，n = 22）。纳入32名健康对照者（HCs）以便与CHB组进行比较。测量了各组的维生素D3水平并进行统计学比较。男性受试者的维生素D3水平较高（41.25±28.85，P < 0.01）。与HC组相比，各CHB组之间未发现关联。尽管存在显著关联，但HCs的维生素D3水平较高，而治疗组、非活动性携带者组和新发病例组的维生素D3水平较低（新发病例[29.82] < 非活动性携带者[32.91] < 治疗组[39.56] < 对照组[44.88]）。在非活动性携带者组（P = 0.171）、治疗组（P = 0.192）和新发病例组（P = 0.369）中，HBV DNA水平与维生素D3水平均无关联。此外，对于任何HBV感染组，丙氨酸转氨酶和天冬氨酸转氨酶水平与维生素D3水平均无关联。维生素D3对CHB患者的临床状态有影响。临床上健康的CHB患者与维生素D3水平之间也可能存在相关性。
