Scanarini M, d'Avella D, Rotilio A, Kitromilis N, Mingrino S
Division of Neurosurgery, University Hospital, Padova, Italy.
J Neurosurg. 1989 Nov;71(5 Pt 1):681-6. doi: 10.3171/jns.1989.71.5.0681.
Idiopathic giant-cell granulomatous hypophysitis is a chronic inflammatory disorder of the pituitary gland. It presents clinically as a sellar mass lesion with pituitary insufficiency and/or hyperprolactinemia, and is radiologically indistinguishable from a pituitary tumor. In most of the previously reported cases the documentation of the disorder has been limited to autopsy tissue. Only a few cases documented by biopsy have been recorded. Four cases are presented here with radiological, endocrinological, and surgical findings. The appropriately documented cases collected from the literature and the present series are reviewed and the incidence, patterns of clinical and radiological presentation, and operative management of this disorder are discussed. This entity should be considered when evaluating patients with a pituitary mass and evidence of hypopituitarism and hyperprolactinemia.
特发性巨细胞肉芽肿性垂体炎是一种垂体的慢性炎症性疾病。临床上表现为鞍区肿块性病变，伴有垂体功能减退和/或高催乳素血症，在放射学上与垂体肿瘤无法区分。在大多数先前报道的病例中，该疾病的记录仅限于尸检组织。仅有少数经活检记录的病例。本文介绍4例患者的放射学、内分泌学和手术结果。对从文献和本系列中收集的记录充分的病例进行回顾，并讨论该疾病的发病率、临床和放射学表现模式以及手术治疗。在评估患有垂体肿块且有垂体功能减退和高催乳素血症证据的患者时，应考虑这一疾病实体。
