Xia Xuelin, Meng Jingjing, Wu Hanxin, Cheng Tanyu, Liu Guohua
Key Laboratory of Resource Chemistry of Ministry of Education, Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, China.
Chem Commun (Camb). 2017 Feb 4;53(10):1638-1641. doi: 10.1039/c6cc09008g. Epub 2017 Jan 18.
Facile construction of a multifunctional heterogeneous catalyst through the assembly of Au/carbene and chiral ruthenium/diamine dual complexes in large-pore mesoporous silica was developed. This enables an efficient one-pot hydration-asymmetric transfer hydrogenation enantioselective tandem reaction of haloalkynes, affording chiral halohydrins with up to 99% enantioselectivity. Combined multifunctionalities, such as substrate-promoted silanol-functionality, BF anion-bonding gold/carbene and covalent-bonding chiral ruthenium/diamine active centers, contributed cooperatively to the catalytic performance.
通过在大孔介孔二氧化硅中组装金/卡宾和手性钌/二胺双配合物，开发了一种简便的多功能非均相催化剂的构建方法。这使得卤代炔烃能够进行高效的一锅水合-不对称转移氢化对映选择性串联反应，得到对映选择性高达99%的手性卤代醇。诸如底物促进的硅醇官能团、BF阴离子键合的金/卡宾和共价键合的手性钌/二胺活性中心等多种功能协同作用，对催化性能有贡献。
