Liu Huan, Liu Sensheng, Zhou Haifeng, Liu Qixing, Wang Chunqin
Research Center of Green Pharmaceutical Technology and Process, Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University Yichang 443002 China
RSC Adv. 2018 Apr 19;8(27):14829-14832. doi: 10.1039/c8ra02224k. eCollection 2018 Apr 18.
A practical one-pot synthesis of chiral alcohols from readily available alkynes tandem catalysis by the combination of CFSOH and a fluorinated chiral diamine Ru(ii) complex in aqueous CFCHOH is described. Very interestingly, the combination of fluorinated catalysts and solvent exhibits a positive fluorine effect on the reactivity and enantioselectivity. A range of chiral alcohols with wide functional group tolerance was obtained in high yield and excellent stereoselectivity under simple and mild conditions.
描述了一种实用的一锅法，通过在水合CFCHOH中CFSOH和氟化手性二胺Ru(ii)配合物的组合串联催化，从容易获得的炔烃合成手性醇。非常有趣的是，氟化催化剂和溶剂的组合对反应性和对映选择性表现出正氟效应。在简单温和的条件下，以高产率和优异的立体选择性获得了一系列具有广泛官能团耐受性的手性醇。
