Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, the Netherlands.
Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.
Am J Transplant. 2017 Aug;17(8):2000-2007. doi: 10.1111/ajt.14199. Epub 2017 Feb 25.
The complement system, as part of the innate immune system, plays an important role in renal transplantation. Complement is involved in the protection against foreign organisms and clearance of apoptotic cells but can also cause injury to the renal allograft, for instance, via antibody binding or in ischemia-reperfusion injury. Numerous polymorphisms in complement factors have been identified thus far; some of them result in different functionalities or alter complement levels. In this review, we provide an overview of the literature on the role of complement polymorphisms in renal transplantation. Furthermore, we discuss functional complement polymorphisms that have not yet been investigated in kidney transplantation. By investigating multiple polymorphisms both in donor and recipient at the same time, a complotype can be constructed. Because the combination of multiple polymorphisms is likely to have a greater impact than a single one, this could provide valuable prognostic information.
补体系统作为先天免疫系统的一部分，在肾移植中起着重要作用。补体参与抵御外来生物和清除凋亡细胞，但也会对肾移植造成损伤，例如通过抗体结合或缺血再灌注损伤。迄今为止，已经鉴定出许多补体因子的多态性；其中一些导致不同的功能或改变补体水平。在这篇综述中，我们提供了补体多态性在肾移植中作用的文献综述。此外，我们还讨论了在肾移植中尚未研究过的功能性补体多态性。通过同时在供体和受者中研究多个多态性，可以构建一个补体基因型。由于多个多态性的组合可能比单个多态性的影响更大，因此这可能提供有价值的预后信息。
