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[一名6个月大女童因肌内注射六价疫苗诱发尼科拉乌综合征]

[Nicolau syndrome induced by intramuscular injection of a hexavalent vaccine in a 6-month-old girl].

作者信息

Stefano Paola C, Garello Mónica, Nolte María F, Lamy Patricia, Giglio Norberto, Castellano Vanesa, Gentile Ángela

机构信息

Servicio de Dermatología, Hospital Nacional de Pediatría Prof. Dr. J. P. Garrahan, Ciudad Autónoma de Buenos Aires, Argentina.

Consultorios Externos, Hospital de Niños Dr. Ricardo Gutiérrez, Ciudad Autónoma de Buenos Aires, Argentina.

出版信息

Arch Argent Pediatr. 2017 Feb 1;115(1):e13-e16. doi: 10.5546/aap.2017.e13.

DOI:10.5546/aap.2017.e13
PMID:28097847
Abstract

Nicolau syndrome, also known as embolia cutis medicamentosa or livedo-like dermatitis, is a sudden tissue necrosis, a rare complication of intramuscular injection of some drugs. We report a case of a 6-month-old girl who received intramuscularly the third dose of hexavalent vaccine (DTaP- HVB-IPV/HIb), and immediately presented a livedoid lesion around the injection site, progressing to necrosis. We reinforce the importance of early diagnosis to perform a suitable treatment and clinical follow-up to avoid ischemic secondary complications.

摘要

尼科劳综合征，也称为药物性皮肤栓塞或类青斑样皮炎，是一种突然发生的组织坏死，是肌肉注射某些药物的罕见并发症。我们报告一例6个月大的女孩，她接受了第三剂六价疫苗（白百破-乙肝-脊灰灭活疫苗/ Hib）的肌肉注射，注射部位周围立即出现青斑样损害，并进展为坏死。我们强调早期诊断对于进行适当治疗和临床随访以避免缺血性继发并发症的重要性。

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引用本文的文献

1
Embolia cutis Medicamentosa (Nicolau syndrome): case series.药物性皮肤栓塞（尼科劳综合征）：病例系列
Front Med (Lausanne). 2023 Nov 2;10:1216781. doi: 10.3389/fmed.2023.1216781. eCollection 2023.