Max-Planck-Institute for Polymer Research , Ackermannweg 10, 55128 Mainz, Germany.
Department of Functional Interfaces, Leibniz Institute of Photonic Technology (IPHT) Jena , Albert-Einstein-Straße 9, 07745 Jena, Germany.
J Am Chem Soc. 2017 Feb 15;139(6):2512-2519. doi: 10.1021/jacs.6b13399. Epub 2017 Feb 7.
Organelle-targeted photosensitization represents a promising approach in photodynamic therapy where the design of the active photosensitizer (PS) is very crucial. In this work, we developed a macromolecular PS with multiple copies of mitochondria-targeting groups and ruthenium complexes that displays highest phototoxicity toward several cancerous cell lines. In particular, enhanced anticancer activity was demonstrated in acute myeloid leukemia cell lines, where significant impairment of proliferation and clonogenicity occurs. Finally, attractive two-photon absorbing properties further underlined the great significance of this PS for mitochondria targeted PDT applications in deep tissue cancer therapy.
细胞器靶向光动力疗法是一种很有前途的方法，其中活性光敏剂（PS）的设计非常关键。在这项工作中，我们开发了一种具有多个线粒体靶向基团和钌配合物的高分子 PS，对几种癌细胞系显示出最高的光毒性。特别是，在急性髓系白血病细胞系中表现出增强的抗癌活性，其中增殖和克隆形成能力显著受损。最后，吸引人的双光子吸收特性进一步强调了这种 PS 对于用于深层组织癌症治疗的线粒体靶向 PDT 应用的重要意义。
