Qiu Kangqiang, Ouyang Miao, Liu Yukang, Huang Huaiyi, Liu Chaofeng, Chen Yu, Ji Liangnian, Chao Hui
MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China.
J Mater Chem B. 2017 Jul 21;5(27):5488-5498. doi: 10.1039/c7tb00731k. Epub 2017 Jul 3.
By integrating targeting, imaging and treatment, organelle-targeted photodynamic therapy (PDT) has been reported to be an effective strategy for cancer therapy. However, targeting leads to the accumulation of photosensitizers (PSs) in the targeted organelles, which leads to a reduction in O generation and fluorescence quenching, especially for the lipophilic mitochondria-targeted PSs. Moreover, because PSs always need exposure to light for a specific period, photobleaching is difficult to avoid. To address these issues, two iridium(iii) complexes with aggregation-induced two-photon emission (AITPE) characteristics were developed. With lipophilicity, the complexes aggregated in water and targeted mitochondria. Owing to their impressive O production quantum yields and excellent two-photon properties in the aggregate states, the complexes were successfully used for mitochondria-targeted two-photon PDT in monolayer cells and multicellular spheroids. Our results highlighted that the use of a PS with aggregation enhanced O generation and fluorescence is an effective solution for aggregation in organelle-targeted PDT.
通过整合靶向、成像和治疗，据报道，细胞器靶向光动力疗法（PDT）是一种有效的癌症治疗策略。然而，靶向会导致光敏剂（PSs）在靶向细胞器中积累，这会导致单线态氧生成减少和荧光猝灭，特别是对于亲脂性线粒体靶向PSs。此外，由于PSs总是需要在特定时间段内暴露于光下，光漂白难以避免。为了解决这些问题，开发了两种具有聚集诱导双光子发射（AITPE）特性的铱（III）配合物。由于具有亲脂性，这些配合物在水中聚集并靶向线粒体。由于它们在聚集态下令人印象深刻的单线态氧产生量子产率和优异的双光子性质，这些配合物成功用于单层细胞和多细胞球体中的线粒体靶向双光子PDT。我们的结果强调，使用具有聚集增强单线态氧生成和荧光的PS是解决细胞器靶向PDT中聚集问题的有效方法。
