Robinson B F, Benjamin N
Department of Medicine, St George's Hospital Medical School, London.
J Hypertens Suppl. 1989 Sep;7(4):S137-9.
Autoregulation was assessed in the forearm vascular bed of 16 men with normal arterial pressure and 19 patients with hypertension. The perfusion pressure was varied by changing the height of the forearm above the heart and blood flow was measured by venous occlusion plethysmography. In normal subjects, autoregulation was weak and flow usually increased more than pressure. In the hypertensive patients autoregulation was, on average, better than in the normal subjects, but the responses varied widely; in some patients, blood flow fell as pressure increased. The pattern of responses observed in the patients could be the result of a functional change in the smooth muscle, but it could also be the result of an increased wall: lumen ratio in the resistance vessels.
在16名动脉血压正常的男性和19名高血压患者的前臂血管床中评估了自动调节功能。通过改变前臂高于心脏的高度来改变灌注压力，并通过静脉阻塞体积描记法测量血流量。在正常受试者中，自动调节功能较弱，血流量通常比压力增加得更多。高血压患者的自动调节功能平均比正常受试者更好，但反应差异很大；在一些患者中，血流量随着压力增加而下降。在患者中观察到的反应模式可能是平滑肌功能改变的结果，但也可能是阻力血管壁与管腔比例增加的结果。
