Aksoy Muhammed Necati Murat, Akdemir Nermin, Kilic Harun, Yilmaz Sabiye, Akdemir Ramazan, Gunduz Huseyin
a Department of Cardiology , Sakarya University Research and Training Hospital , Sakarya , Turkey.
b Department of Obstetrics and Gynecology , Sakarya University Research and Training Hospital , Sakarya , Turkey.
Scand Cardiovasc J. 2017 Apr;51(2):95-98. doi: 10.1080/14017431.2017.1285044. Epub 2017 Feb 7.
Epidemiological studies suggest that women with loss of ovarian function at early ages may be especially burdened by cardiovascular disease (CVD). In this study, we aimed to evaluate pulse wave velocity (PWV) and myocardial performance index (MPI) in patients with premature ovarian insufficiency (POI).
We enrolled 51 female patients (mean age 38.9 ± 6.7 years) with POI and 49 healthy subjects (mean age 36.8 ± 5.2 years). All participants underwent a detailed echocardiographic examination and PWV measurement, which is basically the velocity of pulse wave travelling from carotid to femoral artery.
Both groups were similar with regard to age, body mass index (BMI) and left ventricular ejection fraction. When diastolic functions were assessed, patients with POI had higher mean E/E'ratio (9.3 ± 1.9 vs. 7.6 ± 1.6, p < 0.001). POI patients have impaired MPI (0.9 ± 0.5 vs. 0.5 ± 0.2, p < 0.001) comparing to healthy controls but PWV measurements did not differ between two groups (5.7 ± 0.8 vs. 5.6 ± 0.6 m/s, p = 0.48).
This study showed POI patients might have impaired global left ventricular functions comparing to age matched healthy controls and this might reflect the effects of premature lack of estrogen (E) on women's cardiovascular (CV) system.
流行病学研究表明，早年卵巢功能丧失的女性可能特别容易患心血管疾病（CVD）。在本研究中，我们旨在评估早发性卵巢功能不全（POI）患者的脉搏波速度（PWV）和心肌性能指数（MPI）。
我们招募了51名患有POI的女性患者（平均年龄38.9±6.7岁）和49名健康受试者（平均年龄36.8±5.2岁）。所有参与者均接受了详细的超声心动图检查和PWV测量，PWV基本上是脉搏波从颈动脉传播到股动脉的速度。
两组在年龄、体重指数（BMI）和左心室射血分数方面相似。在评估舒张功能时，POI患者的平均E/E'比值更高（9.3±1.9对7.6±1.6，p<0.001）。与健康对照组相比，POI患者的MPI受损（0.9±0.5对0.5±0.2，p<0.001），但两组之间的PWV测量值没有差异（5.7±0.8对5.6±0.6 m/s，p = 0.48）。
本研究表明，与年龄匹配的健康对照组相比，POI患者可能存在整体左心室功能受损，这可能反映了过早缺乏雌激素（E）对女性心血管（CV）系统 的影响。
