Wang Jie, Pei Yu, Chen Kang, Yan Wenhua, Wang Anping, Li Yijun, Li Jia, Wang Haibing, An Ping, Zhang Linxi, Ye Yingnan, Jin Xinye, Ning Guang, Mu Yiming, Gu Weijun
School of Medicine, Nankai University, Tianjin, China.
Department of Endocrinology, Chinese PLA General Hospital, Beijing, China.
Int J Endocrinol. 2019 Jan 27;2019:4874121. doi: 10.1155/2019/4874121. eCollection 2019.
The aim of this study is to explore the association between the number of childbirths and the progress of atherosclerosis among Chinese women with hypertension or diabetes.
In total, 1159 Chinese parous women from a community longitudinal survey conducted in the communities of Shijingshan district, Beijing, China, were included in our study. They were divided into three groups according to the number of childbirths, and the change in pulse wave velocity (PWV) was as an indicator of the progression of atherosclerosis because the increased PWV reflected the more serious atherosclerosis. After 3 years, we conducted follow-up visits to the subjects. Logistical regression analyses were applied to investigate the relationship between the number of childbirths and the progression of atherosclerotic stiffness and a stratification analysis was performed for history of hypertension and diabetes.
After 3-year follow-up, among women with diabetes, the OR of women with 2 childbirths was significant [3.5 (95% confidence interval 1.5, 7.9)] in model I, [3.1 (95% confidence interval 1.3, 7.2)] in model II, and the OR of women with ≥3 childbirths was significant [4.4 (95% confidence interval 1.3, 14.5)] in model I, [4.1 (95% confidence interval 1.2, 14.3)] in model II. Among women with hypertension, the risk of the progress of atherosclerosis was not significant.
The increasing number of childbirths is associated with the progression of atherosclerotic stiffness among Chinese women with diabetes, independent of a variety of confounding factors.
本研究旨在探讨中国高血压或糖尿病女性的分娩次数与动脉粥样硬化进展之间的关联。
我们纳入了来自中国北京石景山区社区纵向调查的1159名中国经产妇。根据分娩次数将她们分为三组，脉搏波速度（PWV）的变化作为动脉粥样硬化进展的指标，因为PWV升高反映了更严重的动脉粥样硬化。3年后，我们对受试者进行随访。应用逻辑回归分析来研究分娩次数与动脉粥样硬化硬度进展之间的关系，并对高血压和糖尿病病史进行分层分析。
经过3年随访，在糖尿病女性中，分娩2次的女性在模型I中的比值比（OR）显著[3.5（95%置信区间1.5，7.9）]，在模型II中为[3.1（95%置信区间1.3，7.2）]，分娩≥3次的女性在模型I中的OR显著[4.4（95%置信区间1.3，14.5）]，在模型II中为[4.1（95%置信区间1.2，14.3）]。在高血压女性中，动脉粥样硬化进展的风险不显著。
分娩次数增加与中国糖尿病女性的动脉粥样硬化硬度进展相关，独立于多种混杂因素。
