美国播散性球孢子菌病的危险因素
Risk Factors for Disseminated Coccidioidomycosis, United States.
作者信息
Odio Camila D, Marciano Beatriz E, Galgiani John N, Holland Steven M
出版信息
Emerg Infect Dis. 2017 Feb;23(2):308-11. doi: 10.3201/eid2302.160505.
Abstract
Of 150,000 new coccidioidomycosis infections that occur annually in the United States, ≈1% disseminate; one third of those cases are fatal. Immunocompromised hosts have higher rates of dissemination. We identified 8 patients with disseminated coccidioidomycosis who had defects in the interleukin-12/interferon-γ and STAT3 axes, indicating that these are critical host defense pathways.
摘要
在美国，每年发生的15万例新型球孢子菌病感染中，约1%会扩散；其中三分之一的病例是致命的。免疫功能低下的宿主扩散率更高。我们确定了8例播散性球孢子菌病患者，他们的白细胞介素-12/干扰素-γ和STAT3轴存在缺陷，这表明这些是关键的宿主防御途径。
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