Tamma Roberto, Ribatti Domenico
Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, 70124 Bari, Italy.
National Cancer Institute Giovanni Paolo II, 70124 Bari, Italy.
Int J Mol Sci. 2017 Jan 13;18(1):151. doi: 10.3390/ijms18010151.
Bone marrow (BM) is a source of hematopoietic stem cells (HSCs). HSCs are localized in both the endosteum, in the so-called endosteal niche, and close to thin-walled and fenestrated sinusoidal vessel in the center of BM, in the so-called vascular niche. HSCs give rise to all types of mature blood cells through a process finely controlled by numerous signals emerging from the bone marrow niches where HSCs reside. This review will focus on the description of the role of BM niches in the control of the fate of HSCs and will also highlight the role of the BM niches in the regulation of vasculogenesis and angiogenesis. Moreover, alterations of the signals in niche microenvironment are involved in many aspects of tumor progression and vascularization and further knowledge could provide the basis for the development of new therapeutic strategies.
骨髓（BM）是造血干细胞（HSCs）的来源。造血干细胞定位于骨内膜，即所谓的骨内膜龛位，以及骨髓中心靠近薄壁且有窗孔的窦状血管处，即所谓的血管龛位。造血干细胞通过由其所在的骨髓龛位发出的众多信号精细控制的过程，产生所有类型的成熟血细胞。本综述将着重描述骨髓龛位在控制造血干细胞命运中的作用，还将强调骨髓龛位在血管发生和血管生成调节中的作用。此外，龛位微环境中信号的改变涉及肿瘤进展和血管形成的许多方面，进一步了解这些知识可为开发新的治疗策略提供基础。
