The Catholic High-Performance Cell Therapy Center, Division of Regenerative Medicine, College of Medicine, Seoul, Korea.
Stem Cells. 2010 Jul;28(7):1243-9. doi: 10.1002/stem.453.
Two types of stem cell niches in bone marrow (BM), endosteal osteoblastic, and vascular niches are involved in the microenvironmental regulation of hematopoietic stem cells (HSCs). Recently, redundant features of the two niches were identified, based on their common cellular origins or chemical mediators being produced in each niche. In contrast, studies have also revealed that HSCs are localized differentially in the niches with respect to their distinct functional status, and that the biological activity of each niche is differentially influenced by extrinsic conditions. An important question is, therefore, whether these two niches play distinct roles in regulating HSCs and whether they respond differentially to environmental stimuli/stress for "compartmentalized" niche organization in BM. In this review, recent discoveries related to the characteristics of each type of niche and their common or unique features are discussed, along with the possibility of multiniche regulation of HSCs in BM.
两种类型的骨髓（BM）中的干细胞龛，即骨内膜成骨细胞龛和血管龛，参与造血干细胞（HSCs）的微环境调节。最近，基于两个龛之间共同的细胞起源或化学介质的产生，已经确定了它们的冗余特征。相比之下，研究还揭示了 HSCs 根据其不同的功能状态在龛中定位不同，并且每个龛的生物学活性受到外在条件的不同影响。因此，一个重要的问题是，这两个龛在调节 HSCs 方面是否发挥不同的作用，以及它们是否对环境刺激/压力有不同的反应，以实现 BM 中“分区”的龛组织。在这篇综述中，讨论了与每种龛的特征及其共同或独特特征相关的最新发现，以及 BM 中 HSCs 的多龛调节的可能性。
