Baumert Małgorzata, Surmiak Piotr, Walencka Zofia, Mrowiec Ewa, Sodowska Patrycja
Department of Neonatology, School of Medicine in Katowice, Medical University of Silesia in Katowice..
Ginekol Pol. 2016;87(12):805-807. doi: 10.5603/GP.2016.0092.
In recent years, much attention has been given to infants born prematurely, at 34 0/7 to 36 6/7 weeks of gestation (WG), which have been classified as 'late preterm'. Neonates from that subgroup are less physiologically and metabolically mature than term infants. The aim of the study was to determine whether infants born at 34WG can be classified as 'late preterm' or 'preterm' newborns.
A total of 141 newborns were included in the study: 25 born ≤ 33WG, 53 late-preterm newborns, and 63 term infants. Cord-blood neutrophil gelatinase-associated lipocalin (NGAL) and creatinine concentrations were measured in all newborns. Also, the incidence of clinical complications in the early adaptive period during hospitalization was evaluated.
Higher NGAL concentration was noted among preterm newborns as compared to late-preterm neonates (p < 0.05), and term newborns (p < 0.05), especially in children born at 34WG as compared to 35WG (p < 0.001). However, no differences in NGAL concentration were found between neonates born at 35WG and 36WG, as well as children born at 36WG and term infants. A relationship between umbilical NGAL levels and gestational age was observed. Additionally, a statistically significant difference was found in the incidence of respiratory distress syndrome (p < 0.05) and infections (p < 0.05) among neonates born at 34WG as compared to 35WG.
Late preterm neonates should be defined as 'preterm' between 35 0/7 and 36 6/7 WG. Infants born at 34WG should be included in the preterm group.
近年来，妊娠34⁰/₇至36⁶/₇周出生的早产婴儿（被归类为“晚期早产儿”）受到了广泛关注。该亚组的新生儿在生理和代谢方面不如足月儿成熟。本研究的目的是确定妊娠34周出生的婴儿应归类为“晚期早产儿”还是“早产儿”。
本研究共纳入141例新生儿：25例出生时孕周≤33周，53例晚期早产儿，63例足月儿。测量了所有新生儿脐带血中性粒细胞明胶酶相关脂质运载蛋白（NGAL）和肌酐浓度。此外，还评估了住院期间早期适应期临床并发症的发生率。
与晚期早产儿（p<0.05）和足月儿（p<0.05）相比，早产儿的NGAL浓度更高，尤其是妊娠34周出生的婴儿与35周出生的婴儿相比（p<0.001）。然而，妊娠35周和36周出生的新生儿之间以及妊娠36周出生的婴儿与足月儿之间的NGAL浓度没有差异。观察到脐带血NGAL水平与孕周之间存在关联。此外，妊娠34周出生的新生儿与35周出生的新生儿相比，呼吸窘迫综合征（p<0.05）和感染（p<0.05）的发生率存在统计学显著差异。
晚期早产儿应定义为妊娠35⁰/₇至36⁶/₇周之间的“早产儿”。妊娠34周出生的婴儿应纳入早产组。
