Acar Mutlu, Firat Hikmet, Yüceege Melike, Şanal Doğan Aysun, Çalişkan Sinan, Gürdal Canan
Departments of Ophthalmology (M.A., A.Ş.D., S.Ç., C.G.), and Chest Diseases and Sleep Center (H.F., M.Y.), Ministry of Health, Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
Eye Contact Lens. 2018 Sep;44 Suppl 1:S163-S166. doi: 10.1097/ICL.0000000000000361.
The aim of our study was to detect the presence of conjunctivochalasis (CCh) in obstructive sleep apnea (OSA) patients.
We included 54 subjects (41 OSA patients and 14 control subjects) in the study. All the patients were assessed regarding the presence and stage of CCh.
The patients were grouped according to their apnea-hypopnea index as determined during nocturnal polysomnography in our laboratory as mild (12 patients), moderate (16 patients), and severe (13 patients) OSA. The CCh rate was 87.8% in the OSA group and 57.1% in the control group (P=0.022). Mean CCh stage was 1.58±1.24, 2.38±0.88, and 2.15±0.98 in the mild, moderate, and severe OSA groups, respectively, and 0.71±0.72 in the control group (P=0.0001).
The moderate and severe OSA groups were associated with higher rates and more advanced stages of CCh. We believe that detailed conjunctival assessment is necessary for patients with complaints such as burning, stinging, and foreign body sensation, which we frequently confront in daily practice. In particular, young patients diagnosed with CCh must be carefully assessed regarding sleep apnea. In light of the above findings, we suggest that patients with ocular surface symptoms that are not relieved by topical medical treatment should be assessed for CCh and OSA. Longitudinal studies monitoring the response of CCh to OSA treatment are needed to clarify the relationship between CCh and OSA.
我们研究的目的是检测阻塞性睡眠呼吸暂停（OSA）患者中结膜松弛症（CCh）的存在情况。
我们纳入了54名受试者（41名OSA患者和14名对照受试者）进行研究。对所有患者的CCh存在情况和分期进行了评估。
根据我们实验室夜间多导睡眠图测定的呼吸暂停低通气指数，将患者分为轻度（12例）、中度（16例）和重度（13例）OSA。OSA组的CCh发生率为87.8%，对照组为57.1%（P=0.022）。轻度、中度和重度OSA组的平均CCh分期分别为1.58±1.24、2.38±0.88和2.15±0.98，对照组为0.71±0.72（P=0.0001）。
中度和重度OSA组与较高的CCh发生率和更严重的分期相关。我们认为，对于我们在日常实践中经常遇到的有烧灼感、刺痛感和异物感等症状的患者，进行详细的结膜评估是必要的。特别是，被诊断为CCh的年轻患者必须仔细评估是否存在睡眠呼吸暂停。根据上述发现，我们建议对局部药物治疗无法缓解眼表症状的患者进行CCh和OSA评估。需要进行纵向研究来监测CCh对OSA治疗的反应，以阐明CCh与OSA之间的关系。
