Ghaffari Reza, Ghassemi Hamed, Sadeghniiat Haghighi Khosro, Zarei-Ghanavati Mehran, Latifi Golshan, Nebi Kheder Karzan, Masoumi Ahmad, Afshar Pedram
Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Occupational Sleep Research Center, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.
J Curr Ophthalmol. 2024 Oct 16;36(1):42-45. doi: 10.4103/joco.joco_173_23. eCollection 2024 Jan-Mar.
To evaluate the prevalence of dry eye, meibomian gland dysfunction (MGD), and conjunctivochalasis in patients with obstructive sleep apnea (OSA).
We included 37 patients diagnosed with OSA according to polysomnography. The control group comprised 31 subjects. The study participants underwent a complete ophthalmic examination and ocular surface assessment. Meibography was done using infrared imaging. Furthermore, tear meniscus height was measured using anterior segment optical coherence tomography.
The mean age of the OSA and control groups were 50.3 ± 9.0 and 50.3 ± 8.0, respectively ( = 0.77). The mean scale for meibomian gland expression, meibomian gland plugging, and lid margin telangiectasia was similar in both groups. The meiboscores of the upper and lower eyelids were similar in both groups (upper meiboscores of 0.67 ± 0.48 and 0.37 ± 0.49 in OSA and control group, = 0.180 and lower meiboscores of were 0.47 ± 0.57 and 0.22 ± 0.42 in OSA and control group, = 0.179). The mean tear break-up time (TBUT) was significantly lower in the OSA group (8.17 ± 3.70 compared to 11.47 ± 4.52, < 0.001). Upper and lower tear meniscus height were 186.14 ± 40.11 μm and 199.59 ± 37.22 μm and 237.25 ± 82.86 μm and 218.59 ± 68.8 μm in OSA and control group, respectively ( = 0.221, = 0.166). The mean conjunctivochalasis grading score was 0.92 ± 0.72 and 0.81 ± 0.65 in the OSA and control groups, respectively ( = 0.143).
Despite decreased TBUT in patients with OSA, other dry eye parameters are not altered in these patients. Moreover, the frequency of MGD and conjunctivochalasis is not higher in OSA patients.
评估阻塞性睡眠呼吸暂停（OSA）患者干眼、睑板腺功能障碍（MGD）和结膜松弛症的患病率。
我们纳入了37例根据多导睡眠图诊断为OSA的患者。对照组包括31名受试者。研究参与者接受了全面的眼科检查和眼表评估。使用红外成像进行睑板腺造影。此外，使用眼前节光学相干断层扫描测量泪膜半月板高度。
OSA组和对照组的平均年龄分别为50.3±9.0岁和50.3±8.0岁（P = 0.77）。两组睑板腺分泌、睑板腺堵塞和睑缘毛细血管扩张的平均评分相似。两组上下眼睑的睑板腺评分相似（OSA组和对照组上睑睑板腺评分为0.67±0.48和0.37±0.49，P = 0.180；OSA组和对照组下睑睑板腺评分为0.47±0.57和0.22±0.42，P = 0.179）。OSA组的平均泪膜破裂时间（TBUT）显著更低（分别为8.17±3.70秒和11.47±4.52秒，P < 0.001）。OSA组和对照组上下泪膜半月板高度分别为186.14±40.11μm和199.59±37.22μm，以及237.25±82.86μm和218.59±68.8μm（P = 0.221，P = 0.166）。OSA组和对照组结膜松弛分级的平均评分为0.92±0.72和0.81±0.65（P = 0.143）。
尽管OSA患者的TBUT降低，但这些患者的其他干眼参数未改变。此外，OSA患者中MGD和结膜松弛症的发生率并不更高。
