Brasileiro Lízie Emanuelle Eulalio, Barreto Dayanna Patrícia de Carvalho, Nunes Emerson Arcoverde
Universidade Federal do Rio Grande do Norte (UFRN) - Natal (RN), Brazil.
Universidade de São Paulo (USP) - São Paulo (SP), Brazil.
An Bras Dermatol. 2016 Nov-Dec;91(6):791-798. doi: 10.1590/abd1806-4841.20164878.
Among the wide range of symptoms neglected or resistant to conventional treatments in clinical practice, itch is emerging gradually as a theme to be studied. Itch complaints and the negative effects in the quality of life are observed in several medical fields. Although the partially obscure pathophysiology, some researchers decided to check and test the use of psychotropic drugs in resistant itch to conventional topical treatments and antihistamines. The objective of this study was to evaluate scientific evidence in psychotropic use in the treatment of itch of various causes. This is a systematic review of scientific literature. The following databases were used: PubMed, Web of Science, Scopus and Scielo. Randomized controlled trials that should focus on treatment with psychotropic drugs of pruritus of various causes were the inclusion criteria. All articles were analyzed by the authors, and the consensus was reached in cases of disagreement. Fifteen articles were included after analysis and selection in databases, with the majority of clinical trials focusing on psychopharmacological treatment of itch on account of chronic kidney disease. Clinical trials with psychotropic drugs mostly indicated significant improvement in the itching. In most trials of chronic kidney disease as basal disease for itch, greater effectiveness was observed with the use of psychotropic drugs compared with placebo or other antipruritic. However, the small amount of controlled trials conducted precludes the generalization that psychiatric drugs are effective for itch of various causes.
在临床实践中，瘙痒是众多被忽视或对传统治疗有抵抗性的症状之一，它正逐渐成为一个有待研究的主题。在多个医学领域都观察到了瘙痒主诉及其对生活质量的负面影响。尽管其病理生理学部分仍不清楚，但一些研究人员决定检查和测试精神药物在对传统局部治疗和抗组胺药有抵抗性的瘙痒中的应用。本研究的目的是评估精神药物用于治疗各种原因引起的瘙痒的科学证据。这是一项对科学文献的系统综述。使用了以下数据库：PubMed、科学网、Scopus和Scielo。纳入标准是应聚焦于使用精神药物治疗各种原因引起的瘙痒的随机对照试验。所有文章均由作者进行分析，在存在分歧的情况下达成共识。在对数据库进行分析和筛选后，纳入了15篇文章，其中大多数临床试验聚焦于因慢性肾病引起的瘙痒的精神药理学治疗。使用精神药物的临床试验大多表明瘙痒有显著改善。在大多数以慢性肾病作为瘙痒基础疾病的试验中，与安慰剂或其他止痒药相比，使用精神药物观察到了更高的疗效。然而，所进行的对照试验数量较少，无法得出精神药物对各种原因引起的瘙痒都有效的普遍结论。
