Ryu Hyun Kyung, Moon Jong Ho, Heo Hyun Ji, Kim Jong Woon, Kim Yoon Ha
Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, South Korea.
Int J Gynaecol Obstet. 2017 Feb;136(2):145-150. doi: 10.1002/ijgo.12024. Epub 2016 Nov 18.
To evaluate the usefulness of maternal serum c-reactive protein (CRP), lipid peroxide, and oxygen radical absorbance capacity (ORAC), to predict the interval between membrane rupture and delivery in patients with preterm premature rupture of membranes (PPROM).
The present prospective study included patients with singleton pregnancies experiencing PPROM at earlier than 34 weeks of pregnancy who underwent spontaneous vaginal delivery between August 1, 2010 and July 31, 2013 at Chonnam National University Hospital, Republic of Korea. Patients were categorized based on whether delivery occurred within 3 days of PPROM or after. CRP levels, lipid peroxide (using malondialdehyde levels), ORAC, protein carbonyl, and other potential risk factors were compared between the groups.
There were 72 patients included. Maternal serum CRP levels, malondialdehyde levels, and Bishop Score were higher in patients who underwent delivery within 3 days (all P<0.05); ORAC levels were lower among these patients (P=0.002). A receiver operating characteristic curve analysis showed that CRP, malondialdehyde, and ORAC levels were predictive of delivery within 3 days after PPROM.
Maternal serum CRP, malondialdehyde, and ORAC levels at admission were useful in predicting the latent period in patients with PPROM.
评估孕妇血清C反应蛋白（CRP）、脂质过氧化物和氧自由基吸收能力（ORAC）在预测胎膜早破（PPROM）患者胎膜破裂至分娩间隔时间方面的作用。
本前瞻性研究纳入了2010年8月1日至2013年7月31日在韩国全南国立大学医院妊娠34周前发生PPROM且单胎妊娠并经阴道自然分娩的患者。根据分娩是否在PPROM后3天内发生，将患者进行分类。比较两组之间的CRP水平、脂质过氧化物（采用丙二醛水平）、ORAC、蛋白质羰基及其他潜在危险因素。
共纳入72例患者。在3天内分娩的患者，其母血清CRP水平、丙二醛水平和Bishop评分更高（均P<0.05）；这些患者的ORAC水平更低（P=0.002）。受试者工作特征曲线分析显示，CRP、丙二醛和ORAC水平可预测PPROM后3天内的分娩情况。
入院时孕妇血清CRP、丙二醛和ORAC水平有助于预测PPROM患者的潜伏期。
