两名巴西女性加油站工作人员的苯中毒、临床及血液异常情况：两例病例报告
Benzene poisoning, clinical and blood abnormalities in two Brazilian female gas station attendants: two case reports.
作者信息
Santiago Fábio, Lima Simone, Pinheiro Tayná, Silvestre Rafaele Tavares, Otero Ubirani Barros, Tabalipa Marianne Medeiros, Kosyakova Nadezda, Ornellas Maria Helena, Liehr Thomas, Alves Gilda
机构信息
Laboratório de Marcadores Circulantes, Departamento de Patologia e Laboratórios, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Pós-graduação em Ciências Médicas (PGCM), Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
出版信息
BMC Res Notes. 2017 Jan 18;10(1):52. doi: 10.1186/s13104-016-2369-8.
BACKGROUND
Brazilian gas station workers are chronically exposed to benzene, toluene, xylene (BTX) during their working time. Describe below two cases of latin female gas station workers with benzene poisoning symptoms and miscarriage history.
CASE PRESENTATION
In both cases were identified complex chromosomal rearrangements (CCR) with fluorescence in situ hybridization, applied to whole chromosome paints by chromosomes 1, 2 and 4. The lower natural killer cell (NK) cells have also been observed in cases correspondents, especially the rare type of NK (NKbright) in their peripheral blood cells.
CONCLUSIONS
It is known that acquired chromosomal aberrations are positively correlated with cancer and reproductive risk. In concordance, lower NK cytotoxicity increases the risk for cancer, as well. Thus, this is the first study providing hints on a possible causative relation of lower NK cytotoxicity and increase rates of chromosomal rearrangements including CCRs.
背景
巴西加油站工作人员在工作期间长期接触苯、甲苯、二甲苯（BTX）。以下描述了两名有苯中毒症状和流产史的拉丁裔女性加油站工作人员的病例。
病例介绍
在这两个病例中，通过荧光原位杂交技术，将其应用于1、2和4号染色体的全染色体涂染，鉴定出复杂染色体重排（CCR）。在相应病例中还观察到自然杀伤细胞（NK）数量较低，尤其是外周血细胞中罕见类型的NK（NKbright）。
结论
已知获得性染色体畸变与癌症和生殖风险呈正相关。同样，较低的NK细胞毒性也会增加患癌风险。因此，这是第一项研究，提示了较低的NK细胞毒性与包括CCR在内的染色体重排增加率之间可能存在因果关系。
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