胸腺切除术对重症肌无力患者胸腺萎缩的影响：一项对93例患者的回顾性研究。

Effect of thymectomy for thymic atrophy in myasthenia gravis: A retrospective study on 93 patients.

作者信息

Nakahara Keiichi, Nakane Shunya, Nakajima Makoto, Yamashita Satoshi, Mori Takeshi, Ando Yukio

机构信息

Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Department of Molecular Neurology and Therapeutics, Kumamoto University Hospital, Kumamoto, Japan.

出版信息

J Neuroimmunol. 2017 Apr 15;305:182-185. doi: 10.1016/j.jneuroim.2017.01.005. Epub 2017 Jan 12.

DOI:10.1016/j.jneuroim.2017.01.005

PMID:28100409

Abstract

To clarify the efficacy of thymectomy among myasthenia gravis (MG) patients with and without thymoma. We classified MG patients who underwent thymectomy into 3 groups, such as thymic atrophy group, thymic follicular hyperplasia (TFH) group and thymoma group. We compared the data of clinical features and postoperative prognosis at very short-term, short-term, and medium-term. The clinical course of MG patients with atrophic thymus after thymectomy was even better than those of TFH or thymoma, in this retrospective study. However, we found no significant differences in the comparison of mean dose of prednisolone between the 3 groups at each time point.

摘要

为阐明胸腺切除术在伴有或不伴有胸腺瘤的重症肌无力（MG）患者中的疗效。我们将接受胸腺切除术的MG患者分为3组，即胸腺萎缩组、胸腺滤泡增生（TFH）组和胸腺瘤组。我们比较了极短期、短期和中期的临床特征数据及术后预后。在这项回顾性研究中，胸腺切除术后胸腺萎缩的MG患者的临床病程甚至比TFH组或胸腺瘤组的患者更好。然而，我们发现在每个时间点3组之间泼尼松龙平均剂量的比较中没有显著差异。