重症肌无力的最大程度胸腺切除术

Maximal thymectomy for myasthenia gravis.

作者信息

Ashour M H, Jain S K, Kattan K M, al-Daeef A Q, Abdal Jabbar M S, al-Tahan A R, al-Moallami M

机构信息

Division of Thoracic Surgery, King Khalid University Hospital, Riyadh, Saudi Arabia.

出版信息

Eur J Cardiothorac Surg. 1995;9(8):461-4. doi: 10.1016/s1010-7940(05)80083-1.

DOI:10.1016/s1010-7940(05)80083-1

PMID:7495591

Abstract

Maximal thymectomy was carried out in 48 patients with myasthenia gravis (MG). There were 18 males and 30 females. Thymic hyperplasia was found in 38, and atrophic thymus in 8, patients. Two patients had thymoma. In the non-thymomatous myasthenia gravis complete remission was achieved in 16 patients (34.8%) and pharmacological remission in 20 patients (43.5%) thus giving a total remission in 36 (78.3%) patients. Six patients (13%) improved. There was no improvement in four patients. Thus, the overall benefit from thymectomy was 91.4% in this series. We found that sex, age at onset of disease and steroid therapy influenced the outcome of thymectomy. On the other hand, duration of disease, anti-acetylcholine receptor (AntiAchR) antibodies and thymic histology did not have any bearing on the complete remission rate.

摘要

对48例重症肌无力（MG）患者实施了最大程度胸腺切除术。其中男性18例，女性30例。38例患者发现胸腺增生，8例患者胸腺萎缩。2例患者患有胸腺瘤。在非胸腺瘤性重症肌无力患者中，16例（34.8%）实现完全缓解，20例（43.5%）实现药物缓解，因此共有36例（78.3%）患者实现缓解。6例患者（13%）病情改善。4例患者无改善。因此，在本系列研究中，胸腺切除术的总体获益率为91.4%。我们发现，性别、发病年龄和类固醇治疗会影响胸腺切除术的结果。另一方面，病程、抗乙酰胆碱受体（AntiAchR）抗体和胸腺组织学与完全缓解率无关。