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神经炎症的无菌动物模型？

A sterile animal model for neuroinflammation?

机构信息

Department of Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA 94305, USA. Email:

出版信息

Sci Transl Med. 2017 Jan 18;9(373). doi: 10.1126/scitranslmed.aal4994.

DOI:10.1126/scitranslmed.aal4994
PMID:28100836
Abstract

MRI-guided pulsed focused ultrasound combined with systemic infusion of contrast agent microbubbles induces local neuroinflammation in the rat.

摘要

MRI 引导的脉冲聚焦超声联合全身输注造影微泡诱导大鼠局部神经炎症。

相似文献

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A sterile animal model for neuroinflammation?神经炎症的无菌动物模型？
Sci Transl Med. 2017 Jan 18;9(373). doi: 10.1126/scitranslmed.aal4994.
2
Evaluation of permeability, doxorubicin delivery, and drug retention in a rat brain tumor model after ultrasound-induced blood-tumor barrier disruption.超声诱导血脑肿瘤屏障破坏后大鼠脑肿瘤模型中通透性、阿霉素递送及药物潴留的评估
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Enhancement in blood-tumor barrier permeability and delivery of liposomal doxorubicin using focused ultrasound and microbubbles: evaluation during tumor progression in a rat glioma model.使用聚焦超声和微泡增强血肿瘤屏障通透性及脂质体阿霉素递送：大鼠胶质瘤模型肿瘤进展过程中的评估
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Non-Invasive, Focal Disconnection of Brain Circuitry Using Magnetic Resonance-Guided Low-Intensity Focused Ultrasound to Deliver a Neurotoxin.使用磁共振引导的低强度聚焦超声递送神经毒素对脑回路进行非侵入性、局灶性切断
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Antiangiogenic-targeting drug-loaded microbubbles combined with focused ultrasound for glioma treatment.载有抗血管生成靶向药物的微泡联合聚焦超声治疗脑胶质瘤。
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Phosphatidylserine-microbubble targeting-activated microglia/macrophage in inflammation combined with ultrasound for breaking through the blood-brain barrier.炎症条件下靶向结合 PS 微泡的小胶质细胞/巨噬细胞与超声联合突破血脑屏障。
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Localized Down-regulation of P-glycoprotein by Focused Ultrasound and Microbubbles induced Blood-Brain Barrier Disruption in Rat Brain.聚焦超声联合微泡局部下调P-糖蛋白诱导大鼠脑血脑屏障破坏
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Focused ultrasound with microbubbles induces sterile inflammatory response proportional to the blood brain barrier opening: Attention to experimental conditions.聚焦超声联合微泡可诱导与血脑屏障开放程度成正比的无菌性炎症反应：关注实验条件。
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Microbubbles as a novel contrast agent for brain MRI.微泡作为一种用于脑部磁共振成像的新型造影剂。
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引用本文的文献

1
MRI and histological evaluation of pulsed focused ultrasound and microbubbles treatment effects in the brain.磁共振成像和组织学评估脉冲聚焦超声及微泡处理对大脑的影响。
Theranostics. 2018 Sep 9;8(17):4837-4855. doi: 10.7150/thno.24512. eCollection 2018.
2
Reply to Silburt et al.: Concerning sterile inflammation following focused ultrasound and microbubbles in the brain.对西尔伯特等人的回复：关于聚焦超声和微泡在大脑中引发的无菌性炎症
Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6737-E6738. doi: 10.1073/pnas.1711544114. Epub 2017 Aug 10.