Baranowska Monika, Bartoszek Agnieszka
Katedra Chemii, Technologii i Biotechnologii Żywności, Wydział Chemiczny, Politechnika Gdańska.
Postepy Hig Med Dosw (Online). 2016 Dec 31;70(0):1460-1468. doi: 10.5604/17322693.1227896.
In the rational human diet, the important role of fruits and vegetables, which are a source of bioactive phytochemicals, is emphasized. Among fruits particular attention, due to a number of documented health-promoting properties, is focused on cranberry. This fruit is characterized by the high content of antioxidant phenolic compounds, which may support the natural antioxidant defense system of the body in the prevention of damage caused by oxidative stress induced by reactive oxygen species (ROS). Therefore, cranberry is suggested for the prevention of civilization diseases such as atherosclerosis, hypertension and cancer, whose etiology is associated directly with oxidative stress. The health-promoting potential of cranberry is also associated with its antibacterial activity resulting from the presence of proanthocyanidins (PAC) type A with documented anti-adherence properties. The best-established medical applications of cranberry fruits are prevention and treatment of bacterial infections of the urinary tract (UTI), infections of gastric mucosa, and infections of the oral cavity. Due to the widespread use of cranberry and pharmaceutical preparations containing PACs in treating UTI, it is very important to evaluate the absorption, bioavailability and metabolism of these compounds in the human body.
在合理的人类饮食中，水果和蔬菜作为生物活性植物化学物质的来源，其重要作用得到了强调。在水果中，由于有许多已被证实的促进健康的特性，蔓越莓受到了特别关注。这种水果的特点是抗氧化酚类化合物含量高，在预防由活性氧（ROS）诱导的氧化应激所造成的损害方面，可能有助于身体的天然抗氧化防御系统。因此，建议食用蔓越莓来预防诸如动脉粥样硬化、高血压和癌症等文明病，其病因与氧化应激直接相关。蔓越莓的促进健康潜力还与其抗菌活性有关，这种抗菌活性源于具有已被证实的抗黏附特性的A型原花青素（PAC）的存在。蔓越莓果实最确定的医学应用是预防和治疗尿路感染（UTI）、胃黏膜感染和口腔感染。由于蔓越莓和含有PACs的药物制剂在治疗UTI方面的广泛应用，评估这些化合物在人体中的吸收、生物利用度和代谢非常重要。
